Effect of Ionic Liquids on the Fibril-Formation and Gel Properties of Grass Carp (Ctenopharyngodon idellus) Skin Collagen

Zhongwei Zhai; Haibo Wang; Benmei Wei; Peiwen Yu; Chengzhi Xu; Lang He; Juntao Zhang; Yuling Xu

Macromolecular Research, Vol.26, No.7, 609-615, July, 2018

DOI10.1007/s13233-018-6081-5 Export Citation

Effect of Ionic Liquids on the Fibril-Formation and Gel Properties of Grass Carp (Ctenopharyngodon idellus) Skin Collagen

Zhongwei Zhai, Haibo Wang^†, Benmei Wei^†, Peiwen Yu, Chengzhi Xu, Lang He, Juntao Zhang, and Yuling Xu

School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, Hubei, 430023, P. R. China

E-mail:,

Self-assembled environment of collagen is one of the important factors for improving and regulating the properties of collagen-based biomaterials. This study aimed to investigate the effect of ionic liquids (ILs) on the fibril-formation and gel properties of grass carp (Ctenopharyngodon idellus) skin collagen. Fibrillogenic kinetics analysis showed that the collagen self-assembly can be suppressed by the introduction of ILs, and the inhibitory effect is influenced by concentration and types of ILs. Scanning electron microscopy test indicated that the assembled collagen fibrils in the presence of ILs had bigger diameters than that in the conventional buffer. Differential scanning calorimetry analysis revealed that the thermal stability of collagen fibrils can be significantly increased when self-assembly is performed in the presence of ILs. Moreover, the introduction of ILs enhanced the mechanical strength of collagen gels. Finding from this work provides a new idea for improving the performance of fish-sourced collagen biomaterials.

Keywords:Fish-sourced collagen;ionic liquids;fibril formation;collagen gels

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[Referenced By]

[1] Neel EAA, Bozec L, Knowles JC, Syed O, Mudera V, Day R, Hyun JK, Adv. Drug Deliv. Rev., 65, 429 (2013)

[2] Bailey AJ, Robins SP, Balian G, Nature, 251, 105 (1974)

[3] Lee JS, Kim JK, Park SR, Chang YH, Macromol. Res., 15(3), 205 (2007)

[4] Jie Y, Cai Z, Li S, Xie Z, MA M, Huang X, Macromol. Res., 25(9), 905 (2017)

[5] Song JE, Tripathy N, Shin JH, Lee DH, Cha JG, Park CH, Suh DS, Khang G, Macromol. Res., 25(10), 994 (2017)

[6] Song JE, Tripathy N, Shin JH, Lee DH, Park CH, Khang G, Macromol. Res., 24(4), 359 (2016)

[7] Brodsky B, Ramshaw JAM, Matrix Biol., 15, 545 (1997)

[8] Brodsky B, Persikov AV, Adv. Protein Chem., 70, 301 (2005)

[9] Hulmes DJS, J. Struct. Biol., 1372, 2 (2002)

[10] Ottani V, Martini D, Franchi M, Ruggeri A, Raspanti M, Micron, 33, 587 (2002)

[11] Razafiarison T, Silvan U, Meier D, Snedeker JG, Adv. Healthc. Mater., 5, 1481 (2016)

[12] Cen L, Wei L, Cui L, Zhang W, Cao Y, Pediatr. Res., 63, 492 (2008)

[13] Chang SW, Flynn BP, Ruberti JW, Buehler MJ, Biomaterials, 33, 3852 (2012)

[14] Xiong G, Luo H, Zhang C, Zhu Y, Wan Y, Macromol. Res., 23(8), 734 (2015)

[15] Yan M, Li B, Zhao X, Qin S, Food Hydrocoll., 29, 199 (2012)

[16] Li Y, Asadi A, Margo MR, Elliot DP, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 1643 (2009)

[17] Oechsle AM, Landenberger M, Gibis M, Irmscher SB, Kohlus R, Weiss J, Int. J. Biol. Macromol., 79, 518 (2015)

[18] Gopinath A, Reddy SMM, Madhan B, Shanmguam G, Rao JR, Eur. Biophys. J., 43, 643 (2014)

[19] Li J, Liu W, Li G, Int. J. Biol. Macromol., 72, 1097 (2015)

[20] Welton T, Chem. Rev., 99(8), 2071 (1999)

[21] Dai C, Zhang J, Huang C, Lei Z, Chem. Rev., 117, 6881 (2017)

[22] Shah SN, Chellappan LK, Gonfa G, Mutalib MIA, Pilus RBM, Bustam MA, Chem. Eng. J., 284, 487 (2016)

[23] Tomlinson SR, Kehr CW, Lopez MS, Schlup JR, Anthony JL, Ind. Eng. Chem. Res., 53(6), 2293 (2014)

[24] Noritomi H, Minamisawa K, Kamiya R, Kato S, J. Biomed. Sci. Eng., 4, 94 (2011)

[25] Warner L, Gjersing E, Follett SE, Elliott KW, Dzyuba SV, Varga K, Biochem. Biophy. Rep., 8, 75 (2016)

[26] Banerjee C, Roy A, Kundu N, Banik D, Sarkar N, Phys. Chem. Chem. Phys., 18, 14520 (2016)

[27] Bharmoria P, Kumar A, Biochim. Biophy. Acta,, 1860, 1017 (2016)

[28] Meng Z, Zheng X, Tang K, Liu J, Ma Z, Zhao Q, Int. J. Biol. Macromol., 51, 440 (2012)

[29] Hu Y, Liu L, Dan WH, Dan NH, Gu ZP, J. Appl. Polym. Sci., 130(4), 2245 (2013)

[30] Eastoe JE, Biochem. J., 61, 589 (1955)

[31] Wallace DG, Rosenblatt J, Adv. Drug Deliv. Rev., 55, 1631 (2003)

[32] Zeng S, Zhang C, Lin H, Yang P, Hong P, Jiang Z, Food Chem., 116, 879 (2009)

[33] Zhang J, Zou M, Zhang M, Wei B, Xu C, Xie D, Wang H, Food Biophys., 11, 380 (2016)

[34] Pati F, Datta P, Adhikari B, Dhara S, Ghosh K, Mohapatra PKD, J. Biomed. Mater. Res. A, 100, 1068 (2012)

[35] Safandowska M, Pietrucha K, Int. J. Biol. Macromol., 53, 32 (2013)

[36] Ogawa M, Moody MW, Portier RJ, Bell J, Schexnayder MA, Losso JN, J. Agric. Food Chem., 51, 8088 (2003)

[37] Yang H, Wang H, Zhao Y, Wang H, Zhang H, J. Sci. Food Agric., 95, 329 (2015)

[38] Uriarte-Montoya MH, Arias-Moscoso JL, Plascencia-Jatomea M, Santacruz-Ortega H, Rouzaud-Sandez O, Cardenas-Lopez JL, Marquez-Rios E, Ezquerra-Brauer JM, Bioresour. Technol., 101(11), 4212 (2010)

[39] Zhang Y, Liu W, Li G, Shi B, Miao Y, Wu X, Food Chem., 103, 906 (2007)

[40] Li C, Zhong Z, Wan Q, Zhao H, Gu H, Xiong S, Eur. Food Res. Technol., 227, 1467 (2008)

[41] Silver FH, Birk DE, Coll. Relat. Res., 3, 393 (1983)

[42] Cejas MA, Kinney WA, Chen C, Vinter JG, Almond HR, Balss KM, Maryanoff CA, Schmidt U, Breslav M, Mahan A, Lacy E, Maryanoff BE, Proc. Natl. Acad. Sci. U.S.A., 105, 8513 (2008)

[43] Rosenblatt J, Devereux B, Wallace DG, Biomaterials, 15, 985 (1994)

[44] Delorenzi NJ, Sculsky G, Gatti CA, Int. J. Biol. Macromol., 19, 15 (1996)

[45] Kadler KE, Holmes DF, Trotter JA, Chapman JA, Biochem. J., 316, 1 (1996)

[46] Jiang Y, Wang H, Deng M, Wang Z, Zhang J, Wang H, Zhang H, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 59, 1038 (2016)

[47] Christiansen DL, Huang EK, Silver FH, Matrix Biol., 19, 409 (2000)

[48] Nehrer S, Breinan HA, Ramappa A, Young G, Shortkroff S, Louie LK, Sledge CB, Yannas IV, Spector M, Biomaterials, 18, 769 (1997)

[49] Shoulders MD, Raines RT, Annu. Rev. Biochem., 78, 929 (2009)

[50] Zhang J, Wei B, He L, Xu C, Xie D, Paik KW, Wang H, Macromol. Res., 25(11), 1105 (2017)

[51] Komsa-Penkova R, Koynova R, Kostov G, Tenchov BG, Biochim. Biophys. Acta, 1297, 171 (1996)

[52] Burjanadze TV, Tikopulo EI, Privalov PL, Dokl. Akad. Nauk. SSSR, 293, 720 (1987)

[53] Dai W, Wold LE, Dow JS, Kloner RA, J. Am. Coll. Cardiol., 46, 714 (2005)

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[55] Winter HH, Chambon F, J. Rheol., 30, 367 (1986)

[56] Korhonen M, Hellen L, Hirvonen J, Yliruusi J, Int. J. Pharm., 221, 187 (2001)

[57] Lightbody JJ, Am. J. Cosmet. Surg., 6, 17 (1989)

[58] Curti E, Carini E, Tribuzio G, Vittadini E, Food Sci. Technol., 59, 418 (2014)