화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.108, 88-100, April, 2022
DOI10.1016/j.jiec.2021.12.027  Export Citation
Using artificial neural network for design and development of PVA/chitosan/starch/heparinized nZnO hydrogels for enhanced wound healing
Alireza Joorabloo1, Mohammad Taghi Khorasani1, †, Hassan Adeli2, Peiman Brouki Milan3, 4, and Moein Amoupour5
  • 1Biomaterials Department of Iran Polymer and Petrochemical Institute, P. O. BOX 14965/159, Tehran, Iran
  • 2Department of Chemical Egineering, University of Mazandaran, Babolsar, Iran
  • 3Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  • 4Department of Tissue Engineering and Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran
  • 5Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
E-mail:
A study of many individual parameters is required to provide a robust investigation of a system in biomedical applications. A comprehensive understanding of these parameters is achievable by an appropriate experimental model as a valid description to predict the outputs (responses). A combination of response surface methodology and artificial neural network has been employed to design hydrogel dressings including polyvinyl alcohol, chitosan, and starch. The optimal ratio of components of hydrogels as input data based on the water vapor transmission rate, gel content, swelling ratio, and porosity properties as output parameters was determined using the quick propagation algorithm. Zinc-oxide nanoparticles were coupled with heparin and applied in the optimal formulation to investigate its effect on physical and mechanical properties, cytotoxicity, and antibacterial activities as well as in vivo wound healing. Mechanical strength improved in the presence of zinc-oxide nanoparticles. Heparin release reached with the saturation state in a longer period after conjugation onto zinc-oxide nanoparticles. Minimum inhibitory concentration decreased significantly by conjugation of heparin to the nanoparticles and current systems could protect wounds against infections. In vivo wound healing and immunohistochemistry assay indicated accelerated wound closure, re-epithelialization, and skin regeneration for hydrogel dressings containing heparin functionalized zinc-oxide nanoparticles.
Keywords:Artificial neural network;Response surface methodology;Heparin functionalized zinc-oxide;nanoparticles Hydrogel wound dressing;Antibacterial activity;In vivo wound healing
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