화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.103, 239-246, November, 2021
DOI10.1016/j.jiec.2021.07.040  Export Citation
Comparing the cytotoxic effect of light-emitting and organic light-emitting diodes based light therapy on human adipose-derived stem cells
Yu-Jin Kim1, Sung-Won Kim1, Ju-Ro Lee2, Soong Ho Um1, Yoon Ki Joung2, 3, †, and Suk Ho Bhang1, †
  • 1School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
  • 2Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarang-ro 14-gil 5, Seoungbuk-gu, Seoul 02792, Republic of Korea
  • 3Division of Bio-Medical Science & Technology, University of Science and Technology, 113 Gwahangno, Yuseong-gu, Daejeon 305-333, Republic of Korea
E-mail:,
Light has attracted significant attention as a promising tool in the biomedical and cosmetic industries. However, little is known about the cytotoxic effects of conventional light sources based on their physical effects such as temperature and luminance. Here, the cytotoxic effects of representative light sources, a light-emitting diode (LED) and an organic light-emitting diode (OLED), were studied with human adipose-derived stem cells (hADSCs). Regardless of the identical light energy conditions, LED group induced a higher apoptotic activity in hADSCs than the OLED group due to its significant heat generation compared to OLED as further demonstrated with heat shock protein family gene expression. Additionally, we further confirmed the effect of luminance by irradiating light from LED and OLED under the same temperature and energy conditions. Increased cell proliferation was confirmed in the OLED group, and a significant expression of intracellular reactive oxygen species was observed in the LED group without showing heat shock protein upregulation. Taken together, the differences in cytotoxicity and cellular response after LED irradiation compared with OLED irradiation can be varied with temperature and luminance control. This study suggests that OLED based device could be an alternative and promising light source for future biomedical and cosmetic applications.
Keywords:Adipose-derived stem cell;Cell death;Light-emitting diode;Organic light-emitting diode;Phototoxicity;Reactive oxygen species
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