화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.29, No.5, 342-350, May, 2021
DOI10.1007/s13233-021-9040-5  Export Citation
Improvement of Medication Adherence and Controlled Drug Release by Optimized Acetaminophen Formulation
Suyoung Been, Jeongmin Choi, Young Hun Lee, Pil Yun Kim, Won Kyung Kim, Hun Hwi Cho, Ji Eun Lee, Alessio Bucciarelli1, Dae Hoon Lee, Jeong Eun Song, and Gilson Khang†
  • Department of Bionanotechnology and Bio-Convergence Engineering, Department of Polymer Nano Science & Technology and Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Jeonju 54896, Korea
  • 1Center for Materials and Microsystems, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy
E-mail:
Acetaminophen (paracetamol, APAP) is a major component of Tylenol, Penzal Q, and Panpyrin, and is the most commonly used antipyretic analgesic in children. The conventional oral drug delivery systems of APAP are pills and tablets. However alternative drug delivery methods are desirable in case of pediatric or geriatric patients, especially for drugs like APAP that must be taken in large doses at once. Another requirement for a good drug delivery system is the rapid dissolution to ensure a rapid therapeutic action as pain reliever. In this study Acetaminophen (paracetamol, APAP) was encapsulated in a water-soluble polymer. After the preparation of the solid dispersion by encapsulating acetaminophen in polyvinylpyrrolidone, the resultant granules were used in three formulations: tablets, chewable tablets, and oral dissolving films (ODF). Solid dispersions and prepared formulations were evaluated by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffractometer (XRD), and universal tensile machine (UTM), and the release behavior was compared. As a result, it was confirmed that the oral dissolving films can be taken easily because it has the advantages of both tablet and liquid dosage form accurate dosage, easy administration, easy swallowing, and fast bioavailability. Furthermore, the drug absorption rate can be effectively increased by changing the formulation.
Keywords:acetaminophen;chewable tablet;oral dissolving film;formulation;drug release;medication compliance
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