Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers

Won Kyung Kim; Jin Su Kim; Myeong Eun Shin; Jong Seon Baek; David Kim; Alessio Bucciarelli; Jeong Eun Song; Gilson Khang

Macromolecular Research, Vol.28, No.6, 553-557, June, 2020

DOI10.1007/s13233-020-8099-8 Export Citation

Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers

Won Kyung Kim, Jin Su Kim, Myeong Eun Shin, Jong Seon Baek, David Kim, Alessio Bucciarelli¹, Jeong Eun Song , and Gilson Khang^†

Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Materials Fusion Research Center, Chonbuk National University, Deokjin-gu, Jeonju 561-756, Korea
¹Department of Industrial Engineering, University of Trento, via Sommarive 9, Trento, Italy BIOTech Research Center, University of Trento, via delle Regole 101, Trento, Italy and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Trento, Italy

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Nifedipine is a calcium channel blocker widely used for the treatment of blood pressure related diseases such as angina, hypertension and Raynaud. However, since the drug after the administration reaches the highest blood concentration between 30 min and 2 h, its insolubility may expose the patient to various side effects. In this study, nifedipine was prepared as a solid dispersion using a water-soluble polymer (PVP-K30) in order to increase the releasing time and postpone the time at which the drug reaches its highest concentration, thereby increasing its bioavailability. SEM, XRD, DSC, and FT-IR were used for characterization of the solid dispersion. In order to test the release of the drug, a dissolution test was performed with a serous fluid for 12 h. In this work a drug formulation capable of sustained release of nifedipine using a water-soluble polymer was developed.

Keywords:sustained release;nifedipine;solid dispersion

[References]

Khang G, Jeong JK, Rhee JM, Shin HC, Lee HB, in Biomaterials Drug Delivery toward New Millenium, Han Rim Won Publishing Co., p 309 2000.
Hoerter D, Dressman JB, Adv. Drug Deliv. Rev., 25, 3 (1997)
Maheshwari RK, Chaturvedi SC, Jain NK, J. Pharm. Pharmacol., 60, A60 (2008)
Roberts AD, Zhang HF, Int. J. Pharm., 447, 241 (2013)
Prabhu S, Ortega M, Ma C, Int. J. Pharm., 301, 209 (2005)
Vilhelmsen T, Eliasen H, Schaefer T, Int. J. Pharm., 303, 132 (2005)
Liu X, Lu M, Guo ZF, Huang L, Feng X, Wu CB, Pharm. Res., 29, 806 (2012)
Alfei S, Castellaro S, Macromol. Res., 25(12), 1172 (2017)
Silva TD, Arantes VT, Resende JALC, Speziali NL, de Oliveira RB, Soares CDV, Drug Dev. Ind. Pharm., 36, 1348 (2010)
Eloy JD, Saraiva J, de Albuquerque S, Marchetti JM, AAPS PharmSciTech, 13, 1436 (2012)
Wu JX, Yang MS, van den Berg F, Pajander J, Rades T, Rantanen J, Eur. J. Pharm. Sci., 44, 610 (2011)
Sethia S, Squillante E, Int. J. Pharm., 272, 1 (2004)
Takeuchi H, Nagira S, Yamamoto H, Kawashima Y, Int. J. Pharm., 293, 155 (2005)
Obaidi HA, Brocchini S, Buckton G, J. Pharm. Pharmacol., 59, A18 (2007)
Ulmsten U, Andersson KE, Wingerup L, Arch. Gynecol., 229, 1 (1980)
Smith CD, Robert JR, Mckendry, Lancet, 320, 1299 (1982)
Jain SK, Gupta Y, Drug Deliv., 15, 141 (2008)
Mura P, Fauucci MT, Manderioli A, Bramanti G, Ceccarelli L, Pharmaceut. Biomed., 18, 151 (1998)
Damian F, Blaton N, Naesens L, Eur. J. Pharm. Sci., 10, 311 (2000)
Liechty WB, Kryscio DR, Slaughter BV, Peppas NA, Annu. Rev. Chem. Biomol. Eng., 1, 149 (2012)
Yuan X, Xiang TX, Anderson BD, Munson EJ, Mol. Pharmaceut., 12, 4518 (2015)
Porubcan L, Serna C, White J, J. Pharm. Sci., 67, 8 (1978)
Park JY, Lee YH, J. Korean Chem. Soc., 52, 2 (2008)
Jeong HK, Park JY, Kim SY, Cha SR, Lee SE, Jang NK, Lee WT, Lee JP, Song JE, Khang G, Polym. Korea, 40(1), 33 (2016)
Yun HY, Baek MS, Kwon KI, Kor. J. Clin. Pharm., 16, 2 (2006)

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[1] Khang G, Jeong JK, Rhee JM, Shin HC, Lee HB, in Biomaterials Drug Delivery toward New Millenium, Han Rim Won Publishing Co., p 309 2000.

[2] Hoerter D, Dressman JB, Adv. Drug Deliv. Rev., 25, 3 (1997)

[3] Maheshwari RK, Chaturvedi SC, Jain NK, J. Pharm. Pharmacol., 60, A60 (2008)

[4] Roberts AD, Zhang HF, Int. J. Pharm., 447, 241 (2013)

[5] Prabhu S, Ortega M, Ma C, Int. J. Pharm., 301, 209 (2005)

[6] Vilhelmsen T, Eliasen H, Schaefer T, Int. J. Pharm., 303, 132 (2005)

[7] Liu X, Lu M, Guo ZF, Huang L, Feng X, Wu CB, Pharm. Res., 29, 806 (2012)

[8] Alfei S, Castellaro S, Macromol. Res., 25(12), 1172 (2017)

[9] Silva TD, Arantes VT, Resende JALC, Speziali NL, de Oliveira RB, Soares CDV, Drug Dev. Ind. Pharm., 36, 1348 (2010)

[10] Eloy JD, Saraiva J, de Albuquerque S, Marchetti JM, AAPS PharmSciTech, 13, 1436 (2012)

[11] Wu JX, Yang MS, van den Berg F, Pajander J, Rades T, Rantanen J, Eur. J. Pharm. Sci., 44, 610 (2011)

[12] Sethia S, Squillante E, Int. J. Pharm., 272, 1 (2004)

[13] Takeuchi H, Nagira S, Yamamoto H, Kawashima Y, Int. J. Pharm., 293, 155 (2005)

[14] Obaidi HA, Brocchini S, Buckton G, J. Pharm. Pharmacol., 59, A18 (2007)

[15] Ulmsten U, Andersson KE, Wingerup L, Arch. Gynecol., 229, 1 (1980)

[16] Smith CD, Robert JR, Mckendry, Lancet, 320, 1299 (1982)

[17] Jain SK, Gupta Y, Drug Deliv., 15, 141 (2008)

[18] Mura P, Fauucci MT, Manderioli A, Bramanti G, Ceccarelli L, Pharmaceut. Biomed., 18, 151 (1998)

[19] Damian F, Blaton N, Naesens L, Eur. J. Pharm. Sci., 10, 311 (2000)

[20] Liechty WB, Kryscio DR, Slaughter BV, Peppas NA, Annu. Rev. Chem. Biomol. Eng., 1, 149 (2012)

[21] Yuan X, Xiang TX, Anderson BD, Munson EJ, Mol. Pharmaceut., 12, 4518 (2015)

[22] Porubcan L, Serna C, White J, J. Pharm. Sci., 67, 8 (1978)

[23] Park JY, Lee YH, J. Korean Chem. Soc., 52, 2 (2008)

[24] Jeong HK, Park JY, Kim SY, Cha SR, Lee SE, Jang NK, Lee WT, Lee JP, Song JE, Khang G, Polym. Korea, 40(1), 33 (2016)

[25] Yun HY, Baek MS, Kwon KI, Kor. J. Clin. Pharm., 16, 2 (2006)