화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.29, No.5, 351-359, May, 2021
DOI10.1007/s13233-021-9042-3  Export Citation
Graphene Oxide-Modified Polyetheretherketone with Excellent Antibacterial Properties and Biocompatibility for Implant Abutment
Cui Guo, Ran Lu, Xin Wang, and Su Chen†
  • Laboratory of Biomaterials and Biomechanics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Tiantan Xili No. 4, School of Stomatology, Capital Medical University, Tiantan Xili No. 4,, China
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Polyetheretherketone (PEEK) implant abutments are widely used in implant dentistry; however, they do not protect the implant against infections. We demonstrated that graphene oxide (GO) coating enhances the integration between implant surfaces and gingival tissues, which is crucial for peri-implant health. The GO coating was tightly fixed onto the PEEK surface by doping with dopamine which is self-polymerized into poly-dopamine (PDA). The in vitro study included antimicrobial and cellular tests. It revealed the inhibition of bacteria like Porphyromonas gingivalis (P. gingivalis), Fusobacterium nucleatum (F. nucleatum), and Streptococcus mutans (S. mutans). Moreover, it exhibited good adhesion and proliferation of human gingival fibroblasts (HGFs). Our results revealed that the PEEK-PDA-GO coating resisted bacteria and protected soft tissues against peri-implant complications.
Keywords:antibacterial activity;polyetheretherketone;graphene oxide;implant dentistry
  1. Gentleman E, Swain RJ, Evans ND, Boonrungsiman S, Jell G, Ball MD, Shean TAV, Oyen ML, Porter A, Stevens MM, Nat. Mater., 8(9), 763 (2009)
  2. Myshin HL, Wiens JP, J. Prosthet. Dent., 94, 440 (2005)
  3. Puckett SD, Lee PP, Ciombor DM, Aaron RK, Webster TJ, Acta Biomater., 6, 2352 (2010)
  4. de Avila ED, Lima BP, Sekiya T, Torii Y, Ogawa T, Shi W, Lux R, Biomaterials, 67, 84 (2015)
  5. Roguska A, Pisarek M, Malgorzata A, Krzysztof L, J. Biomed. Mater. Res. A, 100, 1954 (2012)
  6. Chua PH, Neoh KG, Kang ET, Wang W, Biomaterials, 29, 1412 (2008)
  7. Monteiro DR, Gorup LF, Takamiya AS, Ruvollo-Filho AC, Camargo ERD, Barbosa DB, Int. J. Antimicrob. Ag., 34, 103 (2009)
  8. Mao C, Xiang Y, Liu X, Cui Z, Yang X, Yeung KWK, Pan H, Wang X, Chu PK, Wu S, ACS Nano, 11, 9010 (2017)
  9. Apeldorn T, Keilholz C, Wolff-Fabris F, Altstadt V, J. Appl. Polym. Sci., 128(6), 3758 (2013)
  10. Peng S, Feng P, Wu P, Huang W, Yang Y, Guo W, Gao C, Shuai C, Sci. Rep., 7, 46604 (2017)
  11. Chen M, Ouyang L, Tao L, Wang H, Liu X, ACS Appl. Mater. Inter., 9, 16824 (2017)
  12. Tomalia DA, Hedstrand DM, Wilson LR, Encyclopedia of Polymer Science and Engineering, John Wiley & Sons, New York, 1988.
  13. Kwon GW, Kim H, Gupta KC, Kang IK, Macromol. Res., 26(2), 128 (2018)
  14. Kurtz SM, Devine JN, Biomaterials, 28, 4845 (2007)
  15. Lu T, Wen J, Qian S, Cao H, Ning C, Pan X, Jiang X, Liu X, Chu PK, Biomaterials, 51, 173 (2015)
  16. Pace N, Marinelli M, Spurio S, J. Arthroplasty, 23, 151 (2008)
  17. Sagomonyants KB, Jarman-Smith ML, Devine JN, Aronow MS, Gronowicz GA, Biomaterials, 29, 1563 (2008)
  18. Novoselov KS, Fal'ko VI, Colombo L, Gellert PR, Schwab MG, Kim K, Nature, 490(7419), 192 (2012)
  19. Zhu YW, Murali S, Cai WW, Li XS, Suk JW, Potts JR, Ruoff RS, Adv. Mater., 22(35), 3906 (2010)
  20. Radic S, Geitner NK, Podila R, Kakinen A, Chen P, Ke PC, Ding F, Sci. Rep., 3, 2273 (2013)
  21. Sun J, Deng Y, Li J, Wang G, He P, Tian S, Bu X, Di Z, Yang S, Ding G, ACS Appl. Mater. Inter., 8, 10226 (2016)
  22. He H, Klinowski J, Forster M, Lerf A, Chem. Phys. Lett., 287, 53 (1998)
  23. Lee DH, Yeo H, Kim GR, Ahn S, Goh M, Ku BC, Lee JH, Park B, You NH, Macromol. Res., 22(12), 1344 (2014)
  24. Lee JE, Lee KR, Nam JA, Kim AS, Lee SY, Lee MS, Kim NW, Yin Y, Park JW, Park SY, Jeong JH, Macromol. Res., 26(12), 1115 (2018)
  25. Dreyer DR, Todd AD, Bielawski CW, Chem. Soc. Rev., 39, 228 (2009)
  26. Chaudhuri B, Bhadra D, Moroni L, Pramanik K, Biofabrication, 7, 15009 (2015)
  27. Yang Y, Asiri AM, Tang Z, Du D, Lin Y, Mater. Today, 16, 365 (2013)
  28. Kim H, Namgug R, Singha K, Oh K, Kim WJ, Bioconjug. Chem., 22, 2558 (2011)
  29. Li N, Zhang Q, Gao S, Song Q, Huang R, Wang L, Liu LW, Dai JW, Tang ML, Cheng GS, Sci. Rep., 3, 1604 (2013)
  30. He J, Zhu X, Qi Z, Wang C, Mao X, Zhu C, He Z, Li M, Tang Z, ACS Appl. Mater. Inter., 7, 5605 (2015)
  31. Jia Z, Shi Y, Xiong P, Zhou W, Cheng Y, Zhang Y, Xi T, Wei S, ACS Appl. Mater. Inter., 8, 17151 (2016)
  32. He J, Zhu X, Qi Z, Wang L, Aldalbahi A, Shi J, Song S, Fan C, Lv M, Tang Z, Part. Part. Syst. Char., 34, 170000 (2017)
  33. Hajipour MJ, Fromm KM, Ashkarran AA, Larramendi IRD, Rojo T, Serpooshan V, Parak WJ, Mahmoudi M, Trends Biotechnol., 30, 499 (2012)
  34. Hu W, Peng C, Luo W, Lv M, Li X, Li D, Huang Q, Fan C, ACS Nano, 4, 4317 (2010)
  35. Zou XF, Zhang L, Wang ZJ, Luo Y, J. Am. Chem. Soc., 138(7), 2064 (2016)
  36. Sanchez VC, Jachak A, Hurt RH, Kane AB, Chem. Res. Toxicol., 25, 15 (2012)
  37. Tu YS, Lv M, Xiu P, Huynh T, Zhang M, Castelli M, Liu ZR, Huang Q, Fan CH, Fang HP, Zhou RH, Nat. Nanotechnol., 8(8), 594 (2013)
  38. Meng J, Zhang P, Wang S, Chem. Asian J., 9, 2004 (2014)
  39. Lee H, Dellatore SM, Miller WM, Messersmith PB, Science, 318, 426 (2007)
  40. Hong S, Na YS, Choi S, Song IT, Kim WY, Lee H, Adv. Funct. Mater., 22(22), 4711 (2012)
  41. Najeeb S, Zafar MS, Khurshid Z, Siddiqui F, J. Prosthodont. Res., 60, 12 (2016)
  42. Koutouzis T, Richardson J, Lundgren T, J. Oral Implantol., 37, 174 (2011)
  43. Hahnel S, Wieser A, Lang R, Clin. Oral Implant. Res., 26, 1297 (2015)
  44. Howling GI, Sakoda H, Antonarulrajah A, Marrs H, Stewart TD, Appleyard S, Rand B, Fisher J, Ingham E, J. Biomed. Mater. Res. B: Appl. Biomater., 67B, 758 (2003)
  45. Schmidlin PR, Stawarczyk B, Wieland M, Attin T, Haemmerle CHF, Fischer J, Dent. Mater., 26, 553 (2010)
  46. Chehroudi B, Gould TR, Brunette DM, J. Biomed. Mater. Res., 26, 493 (1992)
  47. Barbolina I, Woods CR, Lozano N, Kostarelos K, Novoselov KS, Roberts IS, 2D Mater., 3, 25025 (2016)
  48. Pang L, Dai C, Bi L, Guo Z, Fang J, Nanoscale Res. Lett., 12, 564 (2017)
  49. Liu SB, Hu M, Zeng TH, Wu R, Jiang RR, Wei J, Wang L, Kong J, Chen Y, Langmuir, 28(33), 12364 (2012)
  50. Krishnamoorthy K, Umasuthan N, Mohan R, Lee J, Kim SJ, Sci. Adv. Mater., 4, 1111 (2012)
  51. Akhavan O, Ghaderi E, ACS Nano, 4, 5731 (2010)
  52. Ouyang L, Deng Y, Yang L, Shi X, Dong T, Tai Y, Yang W, Chen ZG, Macromol. Biosci., 18, 180003 (2018)
  53. Liu YL, Ai KL, Lu LH, Chem. Rev., 114(9), 5057 (2014)
  54. Guo L, Liu Q, Li G, Shi J, Liu J, Wang T, Jiang G, Nanoscale, 4, 5864 (2012)