Novel and highly efficient lipase-catalyzed esterification of formic acid with hexanol for waste gas reutilization

Jeongbae Seo; Minguk Shin; Jonghwa Lee; Taek Lee; Jong-Min Oh; Chulhwan Park

Journal of Industrial and Engineering Chemistry, Vol.93, 430-435, January, 2021

DOI10.1016/j.jiec.2020.10.022 Export Citation

Novel and highly efficient lipase-catalyzed esterification of formic acid with hexanol for waste gas reutilization

Jeongbae Seo, Minguk Shin, Jonghwa Lee, Taek Lee, Jong-Min Oh¹, and Chulhwan Park^†

Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul 01897, Republic of Korea
¹Department of Electronic Materials Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul 01897, Republic of Korea

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The bioconversion of waste C1 gases into formic acid and hexanol is highly important for the sustainable synthesis of diverse chemicals from non-petrochemical sources and the reduction of greenhouse gas emissions. Herein, we valorized formic acid and hexanol by subjecting them to lipase-catalyzed esterification to afford hexyl formate. The maximum conversion was 98.28% with Novozym 435 of 15 g/L, a formic acid to hexanol molar ratio of 1:5, a reaction temperature of 40 °C, and with 1,2-dichloroethane as a solvent for 1.5 h. The original enzymatic activity was retained even after 20 cycles, while conversion was maintained above 95%. These results may generally contribute to the lipase-catalyzed synthesis of formate esters and be used to efficiently valorize waste C1 gases into short-chain flavored esters.

Keywords:Hexyl formate;Esterification;Bioconversion;Enzyme reusability;C1 gas valorization

[References]

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Phillips JR, Atiyeh HK, Tanner RS, Torres JR, Saxena J, Wilkins MR, Huhnke RL, Bioresour. Technol., 190, 114 (2015)
Schuchmann K, Muller V, Science, 342(6164), 1382 (2013)
Shin M, Seo J, Baek Y, Lee T, Jang M, Park C, Biomolecules, 10(1), 70 (2020)
Baek Y, Lee J, Son J, Lee T, Sobhan A, Lee J, Koo SM, Shin WH, Oh JM, Park C, Polymers, 12(8), 1802 (2020)
Chun J, Sang BI, Biotechnol. Bioprocess Eng., 25(4), 616 (2020)
Kim JY, Yeom SH, Biotechnol. Bioprocess Eng., 25(2), 320 (2020)
Pan J, Ou Z, Tang L, Shi H, Korean J. Chem. Eng., 36(5), 729 (2019)
Chang SW, Shaw JF, Shieh CJ, Food Technol. Biotechnol., 41, 237 (2003)
Chen G, Du H, Jiang B, Miao M, Feng B, J. Mol. Catal. B-Enzym., 133, S439 (2016)
Diaz MDR, Gomez JM, Diaz-Suelto B, Garcia-Sanz A, Eng. Life Sci., 10, 171 (2010)
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Patel D, Saha B, Ind. Eng. Chem. Res., 46(10), 3157 (2007)
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Oh S, Park C, Enzyme Microb. Technol., 69, 19 (2015)
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