Controlled drug release in silicone adhesive utilizing particulate additives

Ji Eun Lee; Gyeong-Hyeon Gwak; Hyeon Mo Cho; Cheol Hyun Kim; Myong Euy Lee; Jae-Min Oh

Korean Journal of Chemical Engineering, Vol.34, No.6, 1600-1603, June, 2017

DOI10.1007/s11814-017-0069-2 Export Citation

Controlled drug release in silicone adhesive utilizing particulate additives

Ji Eun Lee, Gyeong-Hyeon Gwak, Hyeon Mo Cho¹, Cheol Hyun Kim, Myong Euy Lee, and Jae-Min Oh^†

Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwondo 26493, Korea
¹University of College,, Yonsei University, Incheon 21983, Korea

E-mail:

Polydimethylsiloxane (PDMS) based adhesives were prepared by cross-linking tetraethoxyorthosilicate (TEOS) while controlling stoichiometry with PDMS, acid catalyst, and water. Particulate additives, alginate and bentonite, were added during the cross-linking process. Cationic drug lidocaine was incorporated into the adhesive with or without additive, and the time-dependent drug release profile was evaluated in phosphate buffered saline and ethanol, respectively. According to kinetic fitting to power function and parabolic diffusion, both solvent and additive type influenced drug release. In particular, particulate additives were found to suppress or facilitate drug release in water or ethanol, respectively.

Keywords:Silicone Adhesive;Particulate Additives;Lidocaine;Release Media;Release Kinetic

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[2] Tan HS, Pfister WR, Pharm. Sci. Technol. Today, 2, 60 (1999)

[3] Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Buhse LF, Eur. J. Pharm. Biopharm., 64, 1 (2006)

[4] Kumar JA, Pullakandam N, Prabu SL, Gopal V, Int. J. Pharm. Sci. Rev. Res., 3, 49 (2010)

[5] Contessotto L, Ghedini E, Pinna F, Signoretto M, Cerrato G, Crocella V, Chem.-Eur. J., 15, 12043 (2009)

[6] Kim JH, Choi HK, Int. J. Pharm., 236, 81 (2002)

[7] Belanger MC, Marois Y, J. Biomed. Mater. Res., 58, 467 (2001)

[8] Defrere S, Mestagdt M, Riva R, Krier F, Van Langendonckt A, Drion P, Jerome C, Evrard B, Dehoux JP, Foidart JM, Macromol. Biosci., 11, 1366 (2011)

[9] Kim SH, Moon JH, Kim JH, Jeong SM, Lee SH, Biomed. Eng. Lett., 1, 199 (2011)

[10] Havlin J, Westfall D, Olsen S, Soil Sci. Soc. Am. J., 49, 371 (1985)

[11] Nesseem DI, Eid S, El-Houseny S, Life Sci., 89, 430 (2011)

[12] Arora P, Mukherjee B, J. Pharm. Sci., 91, 2076 (2002)

[13] Yang H, Nguyen QT, Ding YD, Long YC, Ping ZH, J. Membr. Sci., 164(1-2), 37 (2000)