화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.34, No.6, 1591-1599, June, 2017
DOI10.1007/s11814-017-0121-2  Export Citation
Recent advancements in bioreactions of cellular and cell-free systems: A study of bacterial cellulose as a model
Muhammad Wajid Ullah1, 2, Mazhar Ul Islam1, 3, Shaukat Khan1, Nasrullah Shah4, and Joong Kon Park1, †
  • 1Department of Chemical Engineering, Kyungpook National University, Daegu 41566, Korea
  • 2Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China
  • 3Department of Chemical Engineering, College of Engineering, Dhofar University, Salalah 211, Oman
  • 4Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan
E-mail:
Conventional approaches of regulating natural biochemical and biological processes are greatly hampered by the complexity of natural systems. Therefore, current biotechnological research is focused on improving biological systems and processes using advanced technologies such as genetic and metabolic engineering. These technologies, which employ principles of synthetic and systems biology, are greatly motivated by the diversity of living organisms to improve biological processes and allow the manipulation and reprogramming of target bioreactions and cellular systems.This review describes recent developments in cell biology, as well as genetic and metabolic engineering, and their role in enhancing biological processes. In particular, we illustrate recent advancements in genetic and metabolic engineering with respect to the production of bacterial cellulose (BC) using the model systems Gluconacetobacter xylinum and Gluconacetobacter hansenii. Besides, the cell-free enzyme system, representing the latest engineering strategies, has been comprehensively described. The content covered in the current review will lead readers to get an insight into developing novel metabolic pathways and engineering novel strains for enhanced production of BC and other bioproducts formation.
Keywords:Biochemical Reactions;Biological Systems;Genetic Manipulation;Metabolic Engineering;Bacterial Cellulose
  1. Hodgman CE, Jewett MC, Metab. Eng., 14, 261 (2012)
  2. Kwok R, Nature, 463, 229 (2010)
  3. Smolke CD, Silver PA, Cell, 144, 855 (2011)
  4. Khalil AS, Collins JJ, Nat. Rev. Genet., 11, 367 (2010)
  5. Purnick PEM, Weiss R, Nat. Rev. Mol. Cell Biol., 10, 410 (2009)
  6. Karr JR, Sanghvi JC, Macklin DN, Gutschow MV, Jacobs JM, Bolival B, Garcia NA, Glass JI, Covert MW, Cell, 150, 389 (2012)
  7. Gorba C, Miyashita O, Tama F, Biophys. J., 94, 1589 (2008)
  8. Bu Z, Callaway DJ, Adv. Protein Chem. Str., Biol., 83, 163 (2011)
  9. Yim H, Haselbeck R, Niu W, Baxley CP, Burgard A, Boldt J, Khandurina J, Trawick JD, Osterhut RE, Stephen R, Estadilla J, Teisam S, Schreyer HB, Andrae S, Yang TH, Lee SY, Burk MJ, Van Dien S, Nat. Chem. Biol., 7, 445 (2011)
  10. Atsumi S, Hanai T, Liao JC, Nature, 451, 86 (2008)
  11. Seo C, Lee HW, Suresh A, Yang JW, Jung JK, Kim YC, Korean J. Chem. Eng., 31(8), 1433 (2014)
  12. Shah N, Ul-Islam M, Khattak WA, Park JK, Carbohydr. Polym., 98, 1585 (2013)
  13. Ul-Islam M, Shah N, Ha JH, Park JK, Korean J. Chem. Eng., 28(8), 1736 (2011)
  14. Ullah MW, Ul-Islam M, Khan S, Kim Ya, Park JK, Carbohydr. Polym., 132, 286 (2015)
  15. Ullah MW, Ul-Islam M, Khan S, Kim Ya, Park JK, Carbohydr. Polym., 136, 908 (2016)
  16. Islam MU, Khan T, Park JK, Carbohydr. Polym., 88, 596 (2012)
  17. Czaja W, Krystynowicz A, Bielecki S, Brown RM, Biomaterials, 27, 145 (2006)
  18. Klemm D, Schumann D, Udhardt U, Marsch S, Prog. Polym. Sci, 26, 1561 (2001)
  19. Islam MU, Khattak WA, Kang M, Kim SM, Khan T, Park JK, Cellulose, 20, 253 (2013)
  20. Islam MU, Khattak WA, Ullah MW, Khan S, Park JK, Cellulose, 21, 433 (2014)
  21. Wong HC, Fear AL, Calhoon RD, Eichinger GH, Mayer R, Amikam D, Benziman M, Gelfand DH, Meade JF, Emerick AW, Bruner R, Benbassat A, Tal R, Proc. Natl. Acad. Sci. U.S.A., 87, 8130 (1990)
  22. Saxena IM, Kudlicka K, Okuda K, Brown RM, J. Bacteriol., 176, 5735 (1994)
  23. Kawano S, Tajima K, Uemori Y, Yamashita H, Erata T, Munekata M, Takai M, DNA Res., 9, 149 (2002)
  24. Masaoka S, Ohe T, Sakota N, J. Ferment. Bioeng., 75(4), 18 (1993)
  25. Dewulf P, Joris K, Vandamme EJ, J. Chem. Technol. Biotechnol., 67(4), 376 (1996)
  26. Colvin JR, Arch. Biochem. Biophys., 70, 294 (1957)
  27. Ullah MW, Khattak WA, Islam MU, Khan S, Park JK, Biochem. Eng. J., 105, 391 (2016)
  28. Tal R, Wong HC, Calhoon R, Gelfand D, Fear AL, Volman G, Mayer R, Ross P, Amikam D, Weinhouse H, Cohen A, Sapir S, Ohana P, Benziman M, J. Bacteriol., 180, 4416 (1998)
  29. Dewulf P, Joris K, Vandamme EJ, J. Chem. Technol. Biotechnol., 67(4), 376 (1996)
  30. Endler A, Rodriguez CS, Persson S, Nat. Chem. Biol., 6, 883 (2010)
  31. Lin FC, Brown RM, Drake RR, Haley BE, J. Biol. Chem., 265, 4782 (1990)
  32. Morgan JLW, McNamara JT, Zimmer J, Nat. Struct. Mol. Biol., 21, 489 (2014)
  33. Ross P, Weinhouse H, Aloni Y, Michaeli D, Ohana PW, Mayer R, Braun S, de Vroom E, van der Marel G, van Boom JG, Benziman M, Nature, 325, 279 (1987)
  34. Shoda M, Sugano Y, Biotechnol. Bioproc. E., 10, 1 (2005)
  35. Standal R, Inversen TG, Coucheron DH, Fjærvik E, Blatny J, Valla S, J. Bacteriol., 176, 665 (1994)
  36. Nakai T, Moriya A, Tonouchi N, Tsuchida T, Yoshinaga F, Horinouchi S, Sone Y, Mori H, Sakai F, Hayashi T, Gene, 213, 93 (1998)
  37. Nakai T, Nishiyama Y, Kuga S, Sugano Y, Shoda M, Biochem. Biophys. Res. Commun., 295(2), 458 (2002)
  38. Zogaj X, Nimtz M, Rohde M, Bokranz W, Romling U, Mol. Microbiol., 39, 1452 (2001)
  39. Romling U, Res. Microbiol., 153, 205 (2002)
  40. Forster AC, Church GM, Genome Res., 17, 1 (2007)
  41. Son C, Song W, Hwang DS, Hong YK, Joo J, Choi YS, Korean J. Chem. Eng., 33(8), 2406 (2016)
  42. Sun I, Shen X, Jain R, Lin Y, Wang J, Sun J, Wang J, Yan Y, Yuan Q, Chem. Soc. Rev., 44, 3760 (2015)
  43. Sawant SS, Salunke BK, Tran TK, Kim BS, Korean J. Chem. Eng., 33(5), 1505 (2016)
  44. Saibuatong OA, Phisalaphong M, Carbohydr. Polym., 79, 455 (2010)
  45. Islam MU, Khan T, Park JK, Carbohydr. Polym., 89, 1189 (2012)
  46. Li HX, Kim SJ, Lee YW, Kee CD, Oh IK, Korean J. Chem. Eng., 28(12), 2306 (2011)
  47. Cienchanska D, Fib. Text. East. Europe, 12, 69 (2004)
  48. Evans BR, O‘Neill HM, Malyvanh VP, Lee I, Woodward J, Biosens. Bioelectron., 18, 917 (2003)
  49. Mahmoudi K, Hosni K, Hamdi N, Srasra E, Korean J. Chem. Eng., 32(2), 274 (2015)
  50. Finkenstadt VL, Appl. Microbiol. Biotechnol., 67(6), 735 (2005)
  51. Kim J, Seo YB, Smart Mater. Struct., 11, 355 (2002)
  52. Khan S, Ul-Islam M, Khattak WA, Ullah MW, Yu B, Park JK, Korean J. Chem. Eng., 32(4), 694 (2015)
  53. Kojima Y, Seto A, Tonouchi N, Tsuchida T, Yoshinaga F, Biosci. Biotechnol. Biochem., 61, 1585 (1997)
  54. Lu H, Jia Q, Chen L, Zhang L, J. Microbiol. Biotechnol., 5, 1 (2016)
  55. Li Z, Wang L, Hua J, Jia S, Zhang J, Liu H, Carbohydr. Polym., 120, 115 (2015)
  56. Kurosumi A, Sasaki C, Yamashita Y, Nakmura Y, Carbohydr. Polym., 76, 333 (2009)
  57. Brown AJ, Chem. Soc. Rev., 49, 432 (1988)
  58. Ha JH, Shah N, Ul-Islam M, Khan T, Park JK, Process Biochem., 46(9), 1717 (2011)
  59. Saied EH, Basta AH, Gobran RH, Polym. -Plast. Technol. Eng., 43, 797 (2004)
  60. Umeda Y, Hirano A, Ishibashi M, Akiyama H, Onizuka T, Ikeuchi M, Inoue Y, DNA Res., 6, 109 (1999)
  61. Jung JY, Khan T, Park JK, Chang HN, Korean J. Chem. Eng., 24(2), 265 (2007)
  62. Khan T, Park JK, Carbohydr. Polym., 73, 438 (2008)
  63. Park JK, Park YH, Jung JY, Biotechnol. Bioproc. E., 8, 83 (2003)
  64. Park JK, Park YH, Jung JY, Biotechnol. Bioproc. E., 9, 383 (2004)
  65. Sutherland IW, Int. Dairy J., 11, 663 (2001)
  66. Nakai T, Sugano Y, Shoda M, Sakakibara H, Oiwa K, Tuzi S, Imai T, Sugiyama J, Takeuchi M, Yamauchi D, Mineyuki Y, J. Bacteriol., 195, 958 (2013)
  67. Tonouchi N, Tahara N, Tsuchida T, Yoshinaga F, Beppu T, Horinouchi S, Biosci. Biotechnol. Biochem., 59, 805 (1995)
  68. Kawano S, Tajima K, Kono H, Erata T, Munekata M, Taka M, J. Biosci. Bioeng., 94(3), 275 (2002)
  69. Koo HM, Song SH, Pyun YP, Kim YS, Biosci. Biotechnol. Biochem., 62, 2257 (1998)
  70. Cavka A, Guo X, Tang SJ, Winestrand S, Jonsson LJ, Hong F, Biotechnol. Biofuel., 6, 1 (2013)
  71. Feng Y, Zhang X, Shen Y, Yoshino K, Feng W, Carbohydr. Polym., 87, 644 (2012)
  72. Castro C, Zuluaga R, Putaux JL, Caro G, Mondragon I, Ganan P, Carbohydr. Polym., 84, 96 (2011)
  73. Moosavi-Nasab M, Yousefi A, Iran. J. Biotechnol., 9, 94 (2011)
  74. Hungund BS, Gupta S, J. Microbio. Biochem. Technol., 5, 127 (2010)
  75. Mikkelsen D, Flanagan BM, Dykes GA, Gidley MJ, J. Appl. Microbiol., 107(2), 576 (2009)
  76. Ha JH, Shehzad O, Khan S, Lee SY, Park JW, Khan T, Park JK, Korean J. Chem. Eng., 25(4), 812 (2008)
  77. Nguyen VT, Flanagan B, Gidley MJ, Dykes GA, Curr. Microbiol., 57(5), 449 (2008)
  78. Keshk SM, Bioproces. Biotechnique., 4, 2 (2014)
  79. Cheng KC, Catchmark JM, Demirci A, Biomacromolecules, 12(3), 730 (2011)
  80. Cheng KC, Catchmark JM, Demirci A, Cellulose, 16, 1033 (2009)
  81. Kim SY, Kim JN, Wee YJ, Park DH, Ryu HW, Appl. Biochem. Biotechnol., 131, 705 (2006)
  82. Bae S, Shoda M, Biotechnol. Prog., 20(5), 1366 (2004)
  83. Park JK, Park YH, Jung JY, Biotechnol. Bioproc. E., 8, 83 (2003)
  84. Brown RM, Willison JHM, Richardson CL, Proc. Nat. Acad. Sci., U.S.A., 73, 4565 (1976)
  85. Haigler CH, In: Zeronian SH, Nevell R, Ellis Horwood:Chichester, England 30 (1985).
  86. Ross P, Mayer R, Benziman M, Micobiol. Mol. Biol. Rev., 55, 35 (1991)
  87. Deng Y, Nagachar N, Fang L, Luan X, Catchmark JM, Tien M, Kao TH, PLOS ONE (2015), DOI:10.1371/journal.pone.0119504.
  88. Williams WS, Cannon RE, Appl. Environ. Microbiol., 55, 2448 (1989)
  89. Tahara N, Yano H, Yoshinaga F, J. Ferment. Bioeng., 83(4), 389 (1997)
  90. Yu X, Atalla RH, Int. J. Biol. Macromol., 19, 145 (1996)
  91. Strap LJ, Latos A, Shim I, Bonetta DT, PLoS ONE, 6, e28015 (2011).
  92. Dewulf P, Joris K, Vandamme EJ, J. Chem. Technol. Biotechnol., 67(4), 376 (1996)
  93. Ishida T, Sugano Y, Nakai T, Shoda M, Biosci. Biotechnol. Biochem., 66, 1677 (2002)