| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 |
22권 2호, p.1830 |
| 발표분야 |
생물화공 |
| 제목 |
Ultrasensitive uranyl ion detection using DNAzyme catalytic reaction-combined NW SERS sensor |
| 초록 |
We developed a surface-enhanced Raman scattering (SERS) sensor combined with a DNAzyme-cleaved reaction for the ultrasensitive and specific detection of uranyl ion (UO22+). The presence of UO22+ in sample induces the cleavage of DNAzyme into enzyme strands and released strands, which include Raman-active molecules. The released strands bind with capture DNAs on the nanowire (NW) sensor and this complex provides SERS signal. The sensing performance of this sensor exhibits a detection limit of 1 pM and high selectivity. Furthermore, we successfully detect uranyl ion in diverse UO22+-contaminated natural water. Based on these results, we anticipate that the practical usefulness of this sensor can be expanded to detect diverse toxic metal ions by applying various ion-specific DNA-based ligands to NW sensors. |
| 저자 |
황지현1, 유승민1, 곽래근2, 김홍기3, 이상엽2, 이경자3, 이민구1, 이창규4, 강태준5, 김봉수4
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| 소속 |
1Department of Chemical and Biomolecular Engineering (BK21 plus program), 2Department of Chemistry, 3KAIST, 4Nuclear Materials Development Division, 5KAERI |
| 키워드 |
바이오칩/나노바이오공학 |
| E-Mail |
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| 원문파일 |
초록 보기 |
