Identification of depigmenting components from Nigella glandulifera Freyn

Dung Nguyen Hoang; Ji-Ean Lee; Eun-Ki Kim

Korean Journal of Chemical Engineering, Vol.28, No.4, 1070-1073, April, 2011

DOI10.1007/s11814-010-0457-3 Export Citation

Identification of depigmenting components from Nigella glandulifera Freyn

Dung Nguyen Hoang, Ji-Ean Lee, and Eun-Ki Kim^†

Department of Biological Engineering, National Research Lab of Skinbioactive Materials, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea

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To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by Chinese plants, N. glandulifrea, was evaluated. The methanol extract of this plant showed significantly down-regulated melanin synthesis in a dose-dependent manner at a non-toxic concentration in cultured B16F10 mouse melanoma cells. This extract was further fractionated by using solvent-solvent partition and silica open column chromatography to identify the active components. From GC-MS data, oleic acid methyl ester was found as one of the depigmenting agents. In conclusion, we suggest that this fraction may be a safe and effective depigmentation agent.

Keywords:Melanogenesis;Depigmenting;Identification

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Roh JS, Han JY, Kim JH, Hwang JK, Biol. Pharm. Bull., 27, 1976 (2004)
Ando H, Wen ZM, Kim HY, Valencia JC, Costin GE, Watabe H, Yasumoto KI, Niki Y, Kondoh H, Ichihashi M, Hearing VJ, Biochem. J., 290, 375 (2006)
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[Related Articles]

[1] Riley PA, Pigment Cell Res., 16, 548 (2003)

[2] Halioua B, Beumont MG, Lune F, Int. J. Dermatology., 39, 801 (2000)

[3] Petit L, Pierard GE, Int. J. Cosmetic Sci., 25, 169 (2003)

[4] Taylor SC, Skin Pharm. Appl. Skin Phys., 12, 139 (1999)

[5] Zawa V, Mhaskar ST, J. Cosmet Dermatol., 3, 234 (2004)

[6] Briganti S, Camera E, Picardo M, Pigment Cell Res., 16, 101 (2003)

[7] Solano F, Briganti S, Picardo M, Ghanem G, Pigment Cell Res., 19, 550 (2006)

[8] Zhu W, Gao J, J. Investig. Dermatol. Symp. Proc., 13, 20 (2008)

[9] Wang KH, Lin RD, Hsu FL, Huang YH, Chang HC, Huang CY, Lee MH, J. Ethnopharmacol., 106, 353 (2006)

[10] Lee HI, Yoo BS, Yoo MA, Byun SY, Korean J. Chem. Eng., 24(4), 655 (2007)

[11] Liu YM, Yang JS, Liu QH, Chem. Pharm. Bull., 52, 454 (2004)

[12] Tian Z, Liu YM, Chen SB, Yang JS, Xiao PG, Wang L, Wu E, Molecular., 11, 693 (2206)

[13] Nguyen DTM, Nguyen DH, Lyun HL, Lee HB, Shin JH, Kim EK, J. Microbiol. Biotechnol., 17, 1585 (2007)

[14] Roh JS, Han JY, Kim JH, Hwang JK, Biol. Pharm. Bull., 27, 1976 (2004)

[15] Ando H, Wen ZM, Kim HY, Valencia JC, Costin GE, Watabe H, Yasumoto KI, Niki Y, Kondoh H, Ichihashi M, Hearing VJ, Biochem. J., 290, 375 (2006)

[16] Ando H, Ryu A, Hashimoto A, Oka M, Ichihashi M, Arch. Dermatol. Res., 290, 375 (1998)