Preparation of Polymer-Coated Magnetite Fine Particles for Immunoassay Magnetic Marker

Jung-Min Moon; Bong-Soo Kim; Yeon-Sil Choi; Jang-Oo Lee; Tae Nakahara; Kohji Yoshinaga

Macromolecular Research, Vol.18, No.8, 793-799, August, 2010

DOI10.1007/s13233-010-0803-7 Export Citation

Preparation of Polymer-Coated Magnetite Fine Particles for Immunoassay Magnetic Marker

Jung-Min Moon, Bong-Soo Kim, Yeon-Sil Choi, Jang-Oo Lee^†, Tae Nakahara¹, and Kohji Yoshinaga¹

Division of Chemical Engineering, Pusan National University, Busan, 609-735, Korea
¹Department of Applied Chemistry, Kyushu Institute of Technology, Sensui, Tobata, Kitakyushu, 804-8550, Japan

E-mail:

Polymer-coated magnetite fine particles with carboxyl groups were developed for applications as an immunoassay magnetic marker. The magnetite composites were prepared using the following method. A hydrophilic macromer with a polymerizable vinyl group at the terminal was adsorbed on the surface of the magnetite fine particles. Subsequently, a hydrophilic vinyl monomer with a carboxyl group and a crosslinking agent were added to carry out a copolymerization reaction. The resulting magnetite composite particles were dispersed stably in an aqueous medium. The composite particles exhibited high antibody binding ability and high-sensitive magnetic properties suitable for applications as magnetic markers.

Keywords:magnetite;radical copolymerization;magnetic marker;immunoassay

[References]

Kortan AR, Hull R, Opila RL, Bawendi MG, Steigerwald ML, Carroll PJ, Brus LE, J. Am. Chem. Soc., 112, 1327 (1990)
Zhou HS, Honma I, Komiyama H, Haus JW, J. Phys. Chem., 97, 895 (1993)
Chang SY, Liu L, Asher SA, J. Am. Chem. Soc., 116(15), 6739 (1994)
Yoshinaga K, Yokoyama T, Kito T, Polym. Adv. Technol., 4, 38 (1992)
Yoshinaga K, Sasao Y, Chem. Lett., 26, 1111 (1997)
Moon JM, Lee MT, Kim BS, Lee JO, Tanaka T, Yoshinaga K, Polym. J., 41, 1 (2009)
Kim BS, Lee KT, Huh PH, Lee DH, Jo NJ, Lee JO, Synth. Met., 159, 1369 (2009)
Weller D, Moser A, IEEE Trans. Magn., 35, 4423 (1999)
Heyon T, Chem. Commun., 8, 927 (2003)
Chikazumi S, Taketomi S, Ukita M, Mizukami K, Miyajima H, Setogawa M, Kurihara Y, J. Magn. Magn. Mater., 65, 245 (1987)
Hong RY, Pan TT, Li HZ, J. Magn. Magn. Mater., 303, 60 (2006)
Hu B, Fuchs A, Huseyin S, Gordaninejad F, Evrensel C, Polymer, 47(22), 7653 (2006)
Weissleder R, Bogdanov A, Neuwelt EA, Papisov M, Adv. Drug Deliv. Rev., 16, 321 (1995)
Sudimack JBA, Lee RJ, Adv. Drug Deliv. Rev., 41, 147 (2000)
Lu AH, Schmidt W, Matossevitch N, Bonnermann H, Tesche B, Bill E, Kiefer W, Schuth F, Angew. Chem.-Int. Edit., 43, 4303 (2004)
Wang L, Bao J, Wang L, Zhang F, Li Y, Chem. Eur. J., 12, 6341 (2006)
Osaka T, Matsunaga T, Nakanishi T, Arakaki A, Niwa D, Iida H, Anal. Biochem., 384, 593 (2006)
Gao L, Wu J, Lyle S, Zehr K, Cao L, Gao D, J. Phys. Chem. C, 112, 17357 (2008)
Zhang G, Liu Y, Zhang C, Hu W, Xu W, Li Z, Liang S, Cao J, Wang Y, J. Nanopart. Res., 11, 441 (2009)
Kang SM, Choi IS, Lee KB, Kim YS, Macromol. Res., 17(4), 259 (2009)
Kamruzzaman Selim KM, Lee JH, Kim SJ, Xing Z, Kang IK, Chang Y, Guo H, Macromol. Res., 14(6), 646 (2006)
Lu AH, Salabas EL, Schuth F, Angew. Chem.-Int. Edit., 46, 1222 (2007)
Huber DL, Small, 1, 482 (2005)
Mizukoshi Y, Shuto T, Masahashi N, Tanabe S, Ultrason. Sonochem., 16, 525 (2009)
Jeong U, Teng XW, Wang Y, Yang H, Xia YN, Adv. Mater., 19(1), 33 (2007)
Xie J, Xu C, Xu Z, Hou Y, Young KL, Wang SX, Pourmand N, Sun S, Chem. Mater., 18, 5401 (2006)
Tian J, Feng YK, Xu YS, Macromol. Res., 14(2), 209 (2006)
Ahmad H, Abdur Rahman M, Jalil Miah MA, Tauer K, Macromol. Res., 16(7), 637 (2008)
Ma D, Guan J, Normandin F, Denommee S, Enright G, Veres T, Simard B, Chem. Mater., 18, 1920 (2006)
Yoshinaga K, Yokoyama T, Kito T, Polym. Adv. Technol., 4, 38 (1993)
Tsubokawa N, Maruyama K, Sone Y, Shimomura M, Colloid Polym. Sci., 267, 511 (1989)
Krenkler KP, Laible R, Hamann K, Angew. Makromol. Chem., 53, 101 (1976)
Chujo Y, Ihara E, Saegusa T, Macromolecules, 22, 2040 (1989)
Enpuku K, Minotani T, Hotta M, Nakahodo A, IEEE Trans. Appl. Supercond., 11, 661 (2001)
Enpuku K, Kuroda D, Yang TQ, Yoshinaga K, IEEE Trans. Appl. Supercond., 13, 371 (2003)

[Referenced By]

[1] Kortan AR, Hull R, Opila RL, Bawendi MG, Steigerwald ML, Carroll PJ, Brus LE, J. Am. Chem. Soc., 112, 1327 (1990)

[2] Zhou HS, Honma I, Komiyama H, Haus JW, J. Phys. Chem., 97, 895 (1993)

[3] Chang SY, Liu L, Asher SA, J. Am. Chem. Soc., 116(15), 6739 (1994)

[4] Yoshinaga K, Yokoyama T, Kito T, Polym. Adv. Technol., 4, 38 (1992)

[5] Yoshinaga K, Sasao Y, Chem. Lett., 26, 1111 (1997)

[6] Moon JM, Lee MT, Kim BS, Lee JO, Tanaka T, Yoshinaga K, Polym. J., 41, 1 (2009)

[7] Kim BS, Lee KT, Huh PH, Lee DH, Jo NJ, Lee JO, Synth. Met., 159, 1369 (2009)

[8] Weller D, Moser A, IEEE Trans. Magn., 35, 4423 (1999)

[9] Heyon T, Chem. Commun., 8, 927 (2003)

[10] Chikazumi S, Taketomi S, Ukita M, Mizukami K, Miyajima H, Setogawa M, Kurihara Y, J. Magn. Magn. Mater., 65, 245 (1987)

[11] Hong RY, Pan TT, Li HZ, J. Magn. Magn. Mater., 303, 60 (2006)

[12] Hu B, Fuchs A, Huseyin S, Gordaninejad F, Evrensel C, Polymer, 47(22), 7653 (2006)

[13] Weissleder R, Bogdanov A, Neuwelt EA, Papisov M, Adv. Drug Deliv. Rev., 16, 321 (1995)

[14] Sudimack JBA, Lee RJ, Adv. Drug Deliv. Rev., 41, 147 (2000)

[15] Lu AH, Schmidt W, Matossevitch N, Bonnermann H, Tesche B, Bill E, Kiefer W, Schuth F, Angew. Chem.-Int. Edit., 43, 4303 (2004)

[16] Wang L, Bao J, Wang L, Zhang F, Li Y, Chem. Eur. J., 12, 6341 (2006)

[17] Osaka T, Matsunaga T, Nakanishi T, Arakaki A, Niwa D, Iida H, Anal. Biochem., 384, 593 (2006)

[18] Gao L, Wu J, Lyle S, Zehr K, Cao L, Gao D, J. Phys. Chem. C, 112, 17357 (2008)

[19] Zhang G, Liu Y, Zhang C, Hu W, Xu W, Li Z, Liang S, Cao J, Wang Y, J. Nanopart. Res., 11, 441 (2009)

[20] Kang SM, Choi IS, Lee KB, Kim YS, Macromol. Res., 17(4), 259 (2009)

[21] Kamruzzaman Selim KM, Lee JH, Kim SJ, Xing Z, Kang IK, Chang Y, Guo H, Macromol. Res., 14(6), 646 (2006)

[22] Lu AH, Salabas EL, Schuth F, Angew. Chem.-Int. Edit., 46, 1222 (2007)

[23] Huber DL, Small, 1, 482 (2005)

[24] Mizukoshi Y, Shuto T, Masahashi N, Tanabe S, Ultrason. Sonochem., 16, 525 (2009)

[25] Jeong U, Teng XW, Wang Y, Yang H, Xia YN, Adv. Mater., 19(1), 33 (2007)

[26] Xie J, Xu C, Xu Z, Hou Y, Young KL, Wang SX, Pourmand N, Sun S, Chem. Mater., 18, 5401 (2006)

[27] Tian J, Feng YK, Xu YS, Macromol. Res., 14(2), 209 (2006)

[28] Ahmad H, Abdur Rahman M, Jalil Miah MA, Tauer K, Macromol. Res., 16(7), 637 (2008)

[29] Ma D, Guan J, Normandin F, Denommee S, Enright G, Veres T, Simard B, Chem. Mater., 18, 1920 (2006)

[30] Yoshinaga K, Yokoyama T, Kito T, Polym. Adv. Technol., 4, 38 (1993)

[31] Tsubokawa N, Maruyama K, Sone Y, Shimomura M, Colloid Polym. Sci., 267, 511 (1989)

[32] Krenkler KP, Laible R, Hamann K, Angew. Makromol. Chem., 53, 101 (1976)

[33] Chujo Y, Ihara E, Saegusa T, Macromolecules, 22, 2040 (1989)

[34] Enpuku K, Minotani T, Hotta M, Nakahodo A, IEEE Trans. Appl. Supercond., 11, 661 (2001)

[35] Enpuku K, Kuroda D, Yang TQ, Yoshinaga K, IEEE Trans. Appl. Supercond., 13, 371 (2003)