High voltage electrical discharges (HVED) and high pressure homogenization (HPH) were compared for extracting intracellular compounds from yeasts. The efficiency of cell disruption was evaluated by measurements of electrical conductivity, UV-spectroscopy, etc. It was shown that the HPH permits better extraction than HVED. The filtrations of yeast suspension were studied in a dead-end stirred cell. The filtration of untreated, HVED and HPH treated yeast suspensions without stirring was governed by cake formation mechanism. The filterability of HVED and especially HPH-treated yeast suspension was very low. Under stirring, different filtration mechanisms were observed for untreated and treated yeast suspensions.