Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst

Bonomi R; Selvestrel F; Lombardo V; Sissi C; Polizzi S; Mancin F; Tonellato U; Scrimin P

Journal of the American Chemical Society, Vol.130, No.47, 15744-15744, 2008

Bonomi R, Selvestrel F, Lombardo V, Sissi C, Polizzi S, Mancin F, Tonellato U, Scrimin P

2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage