The distribution of components defined by the solubility parameter (solubility distribution) is determinant for formation of the colloid-disperse phase in crude oil residues and bitumens and its metastable conditions. Therefore, the solubility distribution is chosen as the basis for modeling of colloid precipitation. A mathematical relation between quantity and quality of precipitates applying different precipitating agents is presented. Results of flocculation-point determination of crude oils have shown that precipitation of crude oil colloids follow rules, which have been derived for polymer solutions. A modified Flory-Huggins interaction parameter is used to determine the criterion for metastability and to investigate the influence of different parameters on it.