화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.19, No.3, 287-294, June, 2008
Export Citation
UV 중합에 의한 이성질체 분리막 제조와 특성
The Preparation of Chiral Separation Membranes by UV Polymerization and its Properties
장은정, 홍주희, 허광범, 김민1, 김병식†
  • 동국대학교 생명ㆍ화학공학과
  • 1동국대학교 안전환경시스템공학과
Eun-Jeong Chang, Joo-Hee Hong, Kwang-Beom Heo, Min Kim1, and Byoung-Sik Kim†
  • Department of Chemical & Biochemical Engineering, Dongguk University, Seoul 100-751, Korea
  • 1Department of Safety & Environmental System Engineering, Dongguk University, Gyeongju 780-714, Korea
E-mail:
초록
본 연구에서는 서로 상반되는 생리 활성을 나타내는 거울상 이성질체를 분리하기 위해 UV 중합법에 의해 이성질체를 인식할 수 있는 분자 인식형 고분자(molecularly imprinted polymers; MIPs) 분리막 제조와 그 분리막을 이용한 이성질체의 분리 선택성에 관한 연구를 수행하였다. 폴리카보네이트(polycarbonate; PC) 막은 기공(pore) 내벽에 작은 spot의 형태로 중합되었고 양성(anodisc; AD) 막은 기공 내벽이 아닌 표면(surface) 부분에 500∼700 nm 정도의 필름(film) 형태로 중합되었다. 한편, 제조된 MIPs 분리막들의 L-트립토판(tryptophane; Trp) 이성질체 용액을 이용한 분리 선택도 비교 결과, 기능성 단량체인 메타아크릴산(methacrylic acid; MAA)에 대하여 가교제인 에틸렌 글리콜 디메타아킬레이트(ethylene glycol dimethacrylate; EGDMA) 90% 이상, 분자제인 메탄올(methanol; MeOH)이 30% 이하 첨가되어 필름 형태로 중합된 AD MIPs 분리막이 3.5의 우수한 선택도를 가졌다.
Molecularly imprinted polymer (MIPs) membranes were prepared by UV polymerization to separate racemates with opposite physiological activity, and then its separation selectivity of racemates was carried out. Likewise, their properties were examined. Polycarbonate (PC) membrane was polymerized as small spot form in pore inner wall, but anodisc (AD) membrane was polymerized as film form with thickness 500∼700 nm onto the membrane surface. Also the study on the separation selectivity of prepared MIPs membranes was carried out in L-Tryptophane (Trp) racemate solution. The results showed that AD MIPs membrane polymerized as a film form, which was achieved by solution polymerizaion consisting of over 90% cross-linking agent (ethylene glycol dimethacrylate; EGDMA) and under 30% dispersing agent (methanol; MeOH), had predominant 3.5 selectivity.
Keywords:molecularly imprinted polymer;MIPs;enantiomer;racemate;chirality
  1. Kim JH, M. S. Dissertation, Chungnam National University, Daejon, Korea (2004)
  2. Tayor DR, Maher K, J. Chromatogr. Sci., 30, 67 (1992)
  3. Wang HY, Wulff G, Sahran A, Angew. Chem. Int. Ed. Engl., 11, 1341 (1972)
  4. Martin G, Laffort P, Oder and Deordorization in the Environ., VCH Publishers, Inc., NY, US (1994)
  5. Marshall E, Science, 229, 1071 (1985)
  6. Marshall E, Chemical and Engineering New, March 19, 38 (1990)
  7. Park YJ, Technology New Brief, KISTI (2003)
  8. Cheong SH, Oh CY, Seo JI, Park JK, Korean J. Biotechnol. Bioeng., 16, 115 (2001)
  9. Ryoo JJ, Polym. Sci. Technol., 13(5), 686 (2002)
  10. Chang EJ, Kim BS, Kim M, Appl. Chem., 7, 439 (2003)
  11. Giorno L, Drioli E, Trends Biotechnol., 18, 339 (2000)
  12. Ahuja S, Et AL, Chiral Separations: Application and Technology, Am. Chem. Soc., Washington, DC (1997)
  13. Mathewkrotz J, Shea KJ, J. Am. Chem. Soc., 118(34), 8154 (1996)
  14. Hong JM, Andersson PE, Qian J, Martin CR, Chem. Mater., 10, 1029 (1998)
  15. Yoshikawa M, Izumi J, Kitao T, Chem. Lett., 25, 611 (1996)
  16. Yoshikawa M, Izumi J, Kitao T, Sakamoto S, Macromolecules, 29(25), 8197 (1996)
  17. Yoshikawa M, Izumi J, Kitao T, Polym. J., 29, 205 (1997)
  18. Wang HY, Kobayashi T, Fujii N, Langmuir, 12(20), 4850 (1996)
  19. Wang HY, Kobayashi T, Fukaya T, Fujii N, Langmuir, 13(20), 5396 (1997)
  20. Kobayashi T, Wang HY, Fujii N, Anal. Chim. Acta, 365, 81 (1998)
  21. Kiyohara S, Nakamura M, Saito K, Sugita K, Sugo T, J. Membr. Sci., 152(2), 143 (1999)
  22. Nakamura M, Kiyohara S, Saito K, Sigita K, Sugo T, Anal. Chem., 71, 1323 (1999)
  23. Tone S, Masawaki T, Hamada T, J. Membr. Sci., 103(1-2), 57 (1995)
  24. Tone S, Masawaki T, Eguchi K, J. Membr. Sci., 118(1), 31 (1996)
  25. Lakshmi BB, Martin CR, Nature, 388(6644), 758 (1997)
  26. Parthasarathy A, Brumlik CJ, Martin CR, Collins GE, J. Membr. Sci., 94, 249 (1994)
  27. Hong JW, UV Curing coatings, Chosun University, Gwangju, Korea (2002)