열 감수성 수화겔인 Methacryloyl-(L)-Alanine Methylester 공중합체

양재승; Yoshida M; Asano M; Kumakura M

Polymer(Korea), Vol.15, No.2, 147-153, April, 1991

Export Citation

열 감수성 수화겔인 Methacryloyl-(L)-Alanine Methylester 공중합체

Methacryloyl -(L)-Alanine Methylester Containing Copolymers as Thermoresponsive Hydrogels

양재승, Yoshida M, Asano M, Kumakura M

초록

새로운 형태의 온도 감수성 수화겔을 방사선 중합법으로 합성하였다. 그중 MA(L)AlaOMe/ HPMA (95/5 vol-%) 공중합겔에 열응답성이 가장 높아 수분흡수가 0℃에서 3,000%서부터 40℃에서 65%로 되었다. 95/5나 90/10(vol-%) 비율의 MA(L)AlaOMe/HPMA 수화겔이 온도에 따라 다른 비율의 수화겔에 비하여 수분흡수가 크게 일어났으며 물리적인 강도도 적당하였다. 반복된 흡탈착 실험에서 이 수화겔들은 60℃까지 가역반응을 보였다. 이들 겔의 표피는 40℃에서 5시간후부터 생기기 시작하였다. 용매로서 메타놀은 가장 큰 원통형 구멍을 형성하는 수화겔을 만드는데 가장 효과적인 물질이었다.

A series of new thermo-sensitive hydrogels was synthesized by gamma-ray irradiation. Among them MA(L)AlaOMe/HPMA copolymer gels showed the highest thermo-response: the water absorption changed from 3,000% at 0℃ to 65% at 40℃. The copolymer having 95/5 or 90/10 MA(L) AlaOMe/HPMA composition demonstrated appropriate sensitivity to the temperature as well as physical strength in water absorption. In repeated use, the hydrogel showed good reversible response up to 60℃. The surface appearence of the gel was created after 5 hours at 40℃. Methanol was the most effective solvent to form the biggest cylindrical pores of the hydrogel.

[References]

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[1] Asano M, Kobunshi Ronbunshu, 39, 621 (1982)

[2] Asano M, Kobunshi Ronbunshu, 40, 525 (1983)

[3] Asano M, Makromol. Chem., 184, 1761 (1983)

[4] Wichterle O, Lim D, Nature, 185, 117 (1960)

[5] Yoshida M, Kobunshi Ronbunshu, 39, 285 (1982)

[6] Yoshida M, J. Biomedical Mater. Res., 19, 615 (1985)

[7] Bae YH, Makromol. Chem. Rapid Commun., 8, 481 (1987)

[8] Bae YH, J. Control. Release, 9, 271 (1989)

[9] Hirai T, Kobunshi Ronbunshu, 46, 613 (1989)

[10] Osada Y, J. Polym. Sci. C: Polym. Lett., 18, 281 (1980)

[11] Kumakura M, Eur. J. Appl. Microbiol. Biotechnol., 6, 13 (1979)

[12] Kumakura M, Eur. Polym. J., 19, 621 (1983)

[13] Yoshida M, J. Macromol. Sci.-Chem., A14, 541 (1980)

[14] Ohmori T, Kawamura M, Kobunshi Ronbunshu, 46, 639 (1989)

[15] Russo PS, "Reversible Polymeric Gels and Related Systems," American Chemical Society, Washington, D.C. (1987)

[16] Tanaka T, Hirokawa Y, Polymer, 35, 236 (1986)