Chemistry Letters, Vol.31, No.3, 302-303, 2002
Catalytic asymmetric 1,3-dipolar cycloaddition of a nitrone bearing a bulky amide moiety to gamma-substituted allylic alcohols
A catalytic asymmetric 1,3-dipolar cycloaddition reaction of a nitrone possessing diisopropyl amide moiety to gamma-substituted allylic alcohols was achieved by using diisopropyl (R, R)-tartrate as a chiral auxiliary to afford the corresponding 3,4,5-trisubstituted isoxazolidines with excellent enantioselectivity up to over 99% ee.