Preparation and Properties of PEG Modified PNVP Hydrogel

Young Kyo Son; Ji-Heung Kim; Young Sil Jeon; Dong June Chung

Macromolecular Research, Vol.15, No.6, 527-532, October, 2007

Export Citation

Preparation and Properties of PEG Modified PNVP Hydrogel

Young Kyo Son, Ji-Heung Kim^{1, †}, Young Sil Jeon¹, and Dong June Chung²

Department of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea
¹Polymer Technology Institute, Sungkyunkwan University, Suwon 440-746, Korea
²Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440-746, Korea

E-mail:

Polymer hydrogel has attracted considerable interest as a soft material which is finding expanding applications in pharmaceutics and various biomedical fields. In this work, modified PNVP hydrogels were synthesized by crosslinking polymerization of NVP monomer in the presence of PEG macromer with a methoxy end. The effect of the tethered PEG chain on the properties of the hydrogel was investigated in terms of its swelling capacity, compression gel strength, and the morphology of the resulting hydrogels. These PEG-modified PNVP hydrogels possessed good biocompatibility and a decreased protein (fibrinogen) adsorption, thereby indicating their potential as novel drug delivery matrices and scaffold for tissue engineering.

Keywords:polymeric hydrogel;PNVP;PEG;biocompatibility

[References]

Dumitriu S, Ed, Polymeric Biomaterials, 2nd Ed., Marcel Dekker, New York (2002)
Abraham S, Brahim S, Ishihara K, Guiseppi-Elie A, Biomaterials, 26, 4767 (2005)
Dziubla TD, Lowman AM, J. Biomed. Mater. Res., 68A, 603 (2004)
Lanza RP, Langer R, Vacanti J, Eds, Principle of Tissue Engineering, 2nd Ed., Academic Press, San Diego (2000)
Cha J, Lee WB, Park CR, Cho YW, Ahn CH, Kwon IC, Macromol. Res., 14(5), 573 (2006)
Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)
Ha DI, Lee SB, Chong MS, Lee YM, Macromol. Res., 14(1), 87 (2006)
Caykara T, Kantoglu O, Polym. Adv. Technol., 15, 134 (2004)
Smith LE, Rimmer S, MacNeil S, Biomaterials, 27, 2806 (2006)
Peppas NA, Ed, Hydrogels in Medicine and Pharmacy, CRC Press, Boca Raton, FL (1986)
Devine DM, Higginbotham CL, Eur. Polym. J., 41, 1272 (2005)
Ajji Z, Othman I, Rosiak JM, Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms, 229, 375 (2005)
Jiao Y, Liu Z, Ding S, Li L, Zhou C, J. Polym. Sci., 101, 1515 (2006)
Desai NP, Hubbell JA, J. Biomed. Mater. Res., 25, 829 (1991)
Hubbell JA, Curr. Opin. Biotechnol., 10, 123 (1999)
Harris MJ, Poly(ethylene glycol) Biotechnical and Biomedical Applications, Prenum Press, New York (1992)
Ratner BD, in Biocompatibility of Clinical Implant Materials, D. F. Williams, Ed., CRC Press, Cleveland, Ohio, 1981, Ch 7
Jung YP, Kim JH, Lee DS, Kim YH, J. Polym. Sci., 104, 2484 (2007)
Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC, Anal. Biochem., 150, 76 (1985)
Park MJ, Kwon MJ, Lee SH, Kim DS, J. Kor. Oph. Opt. Soc., 9, 53 (2004)

[Referenced By]

[Related Articles]

[1] Dumitriu S, Ed, Polymeric Biomaterials, 2nd Ed., Marcel Dekker, New York (2002)

[2] Abraham S, Brahim S, Ishihara K, Guiseppi-Elie A, Biomaterials, 26, 4767 (2005)

[3] Dziubla TD, Lowman AM, J. Biomed. Mater. Res., 68A, 603 (2004)

[4] Lanza RP, Langer R, Vacanti J, Eds, Principle of Tissue Engineering, 2nd Ed., Academic Press, San Diego (2000)

[5] Cha J, Lee WB, Park CR, Cho YW, Ahn CH, Kwon IC, Macromol. Res., 14(5), 573 (2006)

[6] Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)

[7] Ha DI, Lee SB, Chong MS, Lee YM, Macromol. Res., 14(1), 87 (2006)

[8] Caykara T, Kantoglu O, Polym. Adv. Technol., 15, 134 (2004)

[9] Smith LE, Rimmer S, MacNeil S, Biomaterials, 27, 2806 (2006)

[10] Peppas NA, Ed, Hydrogels in Medicine and Pharmacy, CRC Press, Boca Raton, FL (1986)

[11] Devine DM, Higginbotham CL, Eur. Polym. J., 41, 1272 (2005)

[12] Ajji Z, Othman I, Rosiak JM, Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms, 229, 375 (2005)

[13] Jiao Y, Liu Z, Ding S, Li L, Zhou C, J. Polym. Sci., 101, 1515 (2006)

[14] Desai NP, Hubbell JA, J. Biomed. Mater. Res., 25, 829 (1991)

[15] Hubbell JA, Curr. Opin. Biotechnol., 10, 123 (1999)

[16] Harris MJ, Poly(ethylene glycol) Biotechnical and Biomedical Applications, Prenum Press, New York (1992)

[17] Ratner BD, in Biocompatibility of Clinical Implant Materials, D. F. Williams, Ed., CRC Press, Cleveland, Ohio, 1981, Ch 7

[18] Jung YP, Kim JH, Lee DS, Kim YH, J. Polym. Sci., 104, 2484 (2007)

[19] Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC, Anal. Biochem., 150, 76 (1985)

[20] Park MJ, Kwon MJ, Lee SH, Kim DS, J. Kor. Oph. Opt. Soc., 9, 53 (2004)