화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.105, 251-258, January, 2022
DOI10.1016/j.jiec.2021.09.021  Export Citation
Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery
Qingye Meng1, Shuangling Zhong2, Shihao He1, Shihao He1, 3, †, and Xuejun Cui1, 4, †
  • 1College of Chemistry, Jilin University, Changchun 130012, PR China
  • 2College of Resources and Environment, Jilin Agricultural University, Changchun 130118, PR China
  • 3State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, PR China
  • 4Weihai Institute for Bionics-Jilin University, Weihai 264400, PR China
E-mail:,
In the present study, an eco-friendly, biodegradable, biocompatible, non-immunogenic, non-toxic polysaccharide, carboxymethyl cellulose (CMC), derivatived from renewable biomass cellulose, was used for designing and fabrication a folic acid modified pH and reduction dual-responsive carboxymethyl cellulose-based microcapsules (FA-PRCMCs). The curcumin (CUR)-loaded microcapsules (FAPRCMCs@ CUR) were prepared via a quick, efficient and environment-friendly sonochemical method, and were employed for the targeted delivery and pH/reduction dual-stimuli-responsive release of CUR. The excess CUR and ethyl acetate phases could be recycled and reused after preparation of FAPRCMCs@ CUR to avoid wasting resources and polluting the environment. The obtained FA-PRCMCs showed good biocompatibility and targeting in anti-tumor evaluation and endocytosis evaluation in vitro. FA-PRCMCs could effectively reduce the unnecessary damage to normal cells by chemotherapy drugs, and improve the utilization of chemotherapy drugs to reduce therapy costs. FA-PRCMCs could be used as smart targeted delivery vectors and have great clinical application potential.
Keywords:Folic acid;Reductive-responsive;Carboxymethyl cellulose;Microcapsule;Curcumin;Targeted delivery;Sonochemical
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