화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.83, 46-52, March, 2020
DOI10.1016/j.jiec.2019.11.011  Export Citation
Development of silver/graphene oxide nanocomposites for antibacterial and antibiofilm applications
Jaehee Jang, Yonghyun Choi, Masayoshi Tanaka1, and Jonghoon Choi†
  • School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea
  • 1Department of Chemical Science and Engineering, Tokyo Institute of Technology, Tokyo, 152-8550, Japan
E-mail:
Diseases caused by antibiotic-resistant bacteria are challenging to treat, and biofilms, which are polymeric conglomerations of bacterial extracellular polysaccharides, proteins, lipids, and DNA, form rigid barriers that prevent external antibacterial reagents from penetrating. In synergy, antibiotic- resistant bacteria and biofilms are highly resistant to chemicals and antibiotics. To eliminate bacterial biofilms, we prepared silver nanoparticles on graphene oxide (GO) nanosheets to synergistically increase the efficacy of bacterial killing and biofilm removal with the minimum amount of toxicity to mammalian cells. Silver nanoparticles prepared on GO nanosheets were characterized by X-ray diffraction, transmission electron microscopy, and inductively coupled plasma-mass spectrometry. Antibacterial activity was evaluated by colony counting assay and minimum inhibitory concentrations against common bacteria. Finally, the antibiofilm properties of nanocomposites were tested in a microfluidic channel with biofilms formed along channel walls. This study shows the potential of silver nanoparticles on GO nanosheets to inhibit the proliferation of infectious bacteria and the formation of biofilms.
Keywords:Antibacterial;Antibiofilm;Silver nanoparticles;Graphene oxide nanosheets
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