화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.27, No.11, 1124-1135, November, 2019
DOI10.1007/s13233-019-7160-y  Export Citation
Reconstituted Fibril from Heterogenic Collagens-A New Method to Regulate Properties of Collagen Gels
Jian Yang, Haibo Wang1, †, Lang He1, †, Benmei Wei1, Chengzhi Xu1, Yuling Xu1, Juntao Zhang1, and Sheng Li1
  • College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, Hubei, 430000, P. R. China
  • 1School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, Hubei, 430000, P. R. China
E-mail:,
Heterotypic collagen fibril has long been found in the tissues of organisms, which plays an important role in the formation and function of complex structures of organisms. Inspiring by the phenomenon, scholars tried to incubate collagens from different sources into novel collagen materials in vitro, and the forming of heterogenic reconstituted collagen fibrils (RF) was often demonstrated by differential scanning calorimetry (DSC) and fluorescence quenching analysis. In this work, we used two type-I collagens from different species (bovine tendon and grasscarp fish skin) to co-assemble in vitro, and verified the formation of RF from a new rheological perspective. In addition, we also investigated the assembly behavior, surface hydrophilicity and hydrophobicity, microscopic morphology and cell proliferation ability of the RF. The results showed that the assembly rate, surface properties, fibril size, viscoelastic properties of RF can be delicately regulated by the method of heterogenic collagen reconstitution. This study provides new experimental evidence for the reconstitution of heterogenic collagens, and also offers a new means for the regulation of collagen gel performance, which would help to expand the application range of collagen gel materials.
Keywords:bovine tendon collagen;grass carp skin collagen;reconstituted fibril;viscoelastic properties;regu
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