β-Glucan hybridized poly(ethylene glycol) microgels for macrophage-targeted protein delivery

Hyunhyuk Tae; Sora Lee; Chang Seok Ki

Journal of Industrial and Engineering Chemistry, Vol.75, 69-76, July, 2019

DOI10.1016/j.jiec.2019.02.014 Export Citation

β-Glucan hybridized poly(ethylene glycol) microgels for macrophage-targeted protein delivery

Hyunhyuk Tae¹, Sora Lee¹, and Chang Seok Ki^{1, 2, †}

¹Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea
²Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea

E-mail:

Macrophages are crucial target cells for drug delivery due to their important roles in immune responses. An immunomodulating polysaccharide, β-glucan, was incorporated into poly(ethylene glycol) microgels via thiol-ene photo-crosslinking. Hybrid microgels of uniform size were obtained. The incorporation of β- glucan was confirmed by fluorescence observations and changes in surface charges. Cellular uptake test results demonstrated that the hybrid microgels were selectively internalized by murine macrophages. Such selective internalization was induced by β-glucan-mediated phagocytosis. The model drug release assay showed that bovine serum albumin loaded into the microgels was gradually released under both neutral and acidic conditions.

Keywords:Beta-glucan;Poly(ethylene glycol);Microgel;Macrophage

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[7] Asano K, Nabeyama A, Miyake Y, Qiu CH, Kurita A, Tomura M, Kanagawa O, Fujii S, Tanaka M, Immunity, 34, 85 (2011)

[8] Schliehe C, Redaelli C, Engelhardt S, Fehlings M, Mueller M, van Rooijen N, Thiry M, Hildner K, Weller H, Groettrup M, J. Immunol., 187, 2112 (2011)

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[23] Zaki NM, Hafez MM, AAPS PharmSciTech, 13, 411 (2012)

[24] Novak M, Vetvicka V, J. Immunotoxicol., 5, 47 (2008)

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[26] Chan GC, Chan WK, Sze DM, J. Hematol. Oncol., 2, 25 (2009)

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[33] Vermonden T, Censi R, Hennink WE, Chem. Rev., 112(5), 2853 (2012)

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[35] Shih H, Lin CC, Biomacromolecules, 13(7), 2003 (2012)

[36] McCall JD, Anseth KS, Biomacromolecules, 13(8), 2410 (2012)

[37] Fraser AK, Ki CS, Lin CC, Macromol. Chem. Phys., 215, 507 (2014)

[38] Zhang Y, Kong H, Fang Y, Nishinari K, Phillips GO, Bioact. Carbohydr. Diet. Fibre, 1, 53 (2013)

[39] Stenekes RJH, Franssen O, van Bommel EMG, Crommelin DJA, Hennink WE, Int. J. Pharm., 183, 29 (1999)

[40] Fairbanks BD, Schwartz MP, Halevi AE, Nuttelman CR, Bowman CN, Anseth KS, Adv. Mater., 21(48), 5005 (2009)

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[43] Fairbanks BD, Schwartz MP, Bowman CN, Anseth KS, Biomaterials, 30, 6702 (2009)

[44] Upadhyay TK, Fatima N, Sharma D, Saravanakumar V, Sharma R, EXCLI J., 16, 210 (2017)

[45] Nanda JS, Lorsch JR, Methods Enzymol., 536, 87 (2014)

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[47] Hatti-Kaul R, Mol. Biotechnol., 19, 269 (2001)

[48] Bilati U, Allemann E, Doelker E, Pharm. Dev. Technol., 8, 1 (2003)

[49] Kaltsa O, Gatsi I, Yanniotis S, Mandala I, Food Bioprocess Technol., 7, 2038 (2014)

[50] Zhong K, Tong L, Liu L, Zhou X, Liu X, Zhang Q, Zhou S, Int. J. Biol. Macromol., 80, 302 (2015)

[51] Sanchez L, Yi Y, Yu Y, Nanoscale, 9, 288 (2017)

[52] Meng F, Lowell CA, J. Exp. Med., 185, 1661 (1997)

[53] Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S, J. Exp. Med., 197, 1119 (2003)

[54] Legentil L, Paris F, Ballet C, Trouvelot S, Daire X, Vetvicka V, Ferrieres V, Molecules, 20, 9745 (2015)

[55] Liu J, Gunn L, Hansen R, Yan J, Exp. Mol. Pathol., 86, 208 (2009)