화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.67, 396-406, November, 2018
DOI10.1016/j.jiec.2018.07.014  Export Citation
Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures
Cheol-Min Han1, 2, Eugene Lih1, Seul-Ki Choi1, Tarek M. Bedair1, 3, Young-Jae Lee4, Wooram Parke5, Dong Keun Han5, †, Jun Sik Son6, †, and Yoon Ki Joung1, 7, †
  • 1Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
  • 2Department of Carbon and Nano Materials Engineering, Jeonju University, Jeonju-si, Jeollabuk-do, 55069, Republic of Korea
  • 3Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt
  • 4S&G Biotech Inc., Seongnam-si, Gyeonggi-do 13229, Republic of Korea
  • 5Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Republic of Korea
  • 6Korea Textile Development Institute, Daegu 41842, Republic of Korea
  • 7Division of Bio-Medical Science and Technology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea
E-mail:, ,
In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid.dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.
Keywords:Esophageal stent;Polydioxanone;Poly(L-lactic acid);Sheath-core monofilament;Surface treatments
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