Preparation of antibacterial TiO2 particles by hybridization with azelaic acid for applications in cosmetics

Hui Jun Leong; Seong-Geun Oh

Journal of Industrial and Engineering Chemistry, Vol.66, 242-247, October, 2018

DOI10.1016/j.jiec.2018.05.035 Export Citation

Preparation of antibacterial TiO2 particles by hybridization with azelaic acid for applications in cosmetics

Hui Jun Leong, and Seong-Geun Oh^†

Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea

E-mail:

To apply as the antimicrobial agent in cosmetics, azelaic acid, a skin lightening material with anti- inflammatory and antimicrobial properties, has been employed to functionalize TiO2 microspheres. Prior to the functionalizationprocess, TiO2microspheres were modified with NaOH to introduce hydroxyl groups on the surface of TiO2 as chemical binders. Hybridization was performed by condensation reaction between hydroxyl groups introduced on the surface of TiO2 by hydroxylation process and the hydroxyl groups of azelaic acid. The azelaic acid-TiO2 composites showed high antimicrobial activities towards both gram positive and gram negative bacterial strains, which are Staphylococcus aureus and Escherichia coli.

Keywords:Antimicrobial effect;TiO2;Azelaic acid;Hybridization;Cosmetics

[References]

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[1] Jowett S, Ryan T, Soc. Sci. Med., 20, 425 (1985)

[2] Paller AS, Mancini AJ, Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood and Adolescence, Elsevier Health Sciences, 2015.

[3] Dominguez-DelgadoCL, Rodriguez IM, Escobar-Chavez JJ, Calderon-Lejero IO, Quintanar-Guerrero DQ, Eur. J. Pharm. Biopharm., 79, 102 (2011)

[4] Segre JA, J. Clin. Invest., 116, 1150 (2006)

[5] Grice EA, Segre JA, Nat. Rev. Microbiol., 9, 244 (2011)

[6] Fredricks DN, J. Investig. Dermatol. Symp. Proc. (2001) Elsevier.

[7] Yamasaki K, Nado AD, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL, Nat. Med., 13, 975 (2007)

[8] Callender VD, Dermatol. Ther., 17, 184 (2004)

[9] Del Rosso JQ, Expert Opin. Pharmacother., 5, 5 (2004)

[10] Vargas E, Hoffmann MA, Bravo B, Malgazhdarova G, Katkhanova OA, Yutskovskaya Y, Skin Pharmacol. Physiol., 27, 18 (2013)

[11] Webster GF, BMJ, 325, 475 (2002)

[12] Weber K, Siebert J, SOFW J., 129, 44 (2003)

[13] Patravale V, Mandawgade S, Int. J. Cosmet. Sci., 30, 9 (2008)

[14] Sanchez C, Soler JA, Robert F, Lalot T, Mayer CR, Cabuil V, Chem. Mater., 13, 3061 (2001)

[15] Mei YF, Huang GS, Solovev AA, Urena EB, Moench I, Ding F, Reindl T, Fu RKY, Chu PK, Schmidt OG, Adv. Mater., 20(21), 4085 (2008)

[16] Dave BC, Med. Coatings Deposition Technol., 373 (2016).

[17] Kobayashi M, Fujiwara Y, Goda M, Komeda H, Shimizu S, Proc. Natl. Acad. Sci. U. S. A., 94, 11986 (1997)

[18] Crowther JM, Sieg A, Blenkiron P, Marcott C, Matta PJ, Kaczvinsky JR, Rawlings AV, Br. J. Dermatol., 159, 567 (2008)

[19] Tarbuk A, Grancaric AM, Situm M, Autex Res. J., 16, 19 (2016)

[20] Leong HJ, Hyun KS, Jung SK, Hong GH, Jeong HA, Oh SG, Int. J. Cosmet. Sci., 38, 524 (2016)

[21] Gazquez JP, Garcia-Tenorio R, Vaca F, Mater. Sci. Appl., 5, 46456 (2014)

[22] Auer G, Woditsch P, Westerhaus A, Kischkewitz J, Griebler WD, Liedekerke MD, Pigments, inorganic, 2. White pigments, Ullmann’s Encyclopedia of Industrial Chemistry, (2009).

[23] Balouiri M, Sadiki M, Ibnsouda SK, J. Pharm. Anal., 6, 71 (2016)

[24] Macwan DP, Dave PN, Chaturvedi S, J. Mater. Sci., 46(11), 3669 (2011)

[25] Silva CG, Juarez R, Marino T, Molinari R, Garcia H, J. Am. Chem. Soc., 133, 595 (2010)

[26] Warheit DB, Webb TR, Sayer CM, Colvin VL, Reed KL, Toxicol. Sci., 91, 227 (2006)

[27] Arranz A, Palacio C, J. Phys. Chem. B, 106(37), 9590 (2002)

[28] Jang I, Park JH, Song K, Kim L, Lee Y, Oh SG, Mater. Chem. Phys., 147(3), 691 (2014)

[29] Sun RD, Nakajima A, Fujishima A, Watanabe T, Hashimoto K, J. Phys. Chem. B, 105(10), 1984 (2001)