화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.59, 251-258, March, 2018
DOI10.1016/j.jiec.2017.10.030  Export Citation
Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery
Qi Lei Wang, Jia Wei Ren1, Bo Zhi Chen, Xuan Jin, Can Yang Zhang2, †, and Xin Dong Guo†
  • Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China
  • 1North China Electric Power University Hospital, Beijing 102206, PR China
  • 2Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA 99210, USA
E-mail:,
Dissolving microneedles (DMNs) prepared from soluble polymers has been being widely investigated as a safe and effective transdermal delivery system for drug and vaccine. Limited by the materials, the air humidity would probably affect the mechanical property of DMNs, which is essential for the effective needle insertions and drug delivery. In this study, four kinds DMNs prepared by polyvinyl alcohol, sodium hyaluronate (HA), chitosan and gelatin are studied on the mechanical strength and insertion ability under varying humidity conditions. Based on these investigations, we hope to provide the effective time of DMNs to ensure a successful insertion and drug delivery.
Keywords:Dissolving microneedle;Mechanical property;Humidity
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