Bi-functional Ni/H-ZSM-22 catalysts with melt infiltration, incipient wetness impregnation and wet impregnation methods, were used to catalyze palmitic acid. Compared to parent zeolite, there were decrease of relative crystallinity, some blockage effects of micro pores and less strong acid sites after Ni loading. The complete conversion of palmitic acid and 100% alkanes selectivity were achieved at lower temperature (200 degrees C). No deactivation was observed in five recycle reaction, indicating the excellent catalytic performance and stability of Ni/H-ZSM-22 catalysts. Higher reaction temperature (240-260 degrees C), more iso-alkanes/n-alkanes formed, while less C-16/C-15 produced. Additionally, the catalysts prepared by melt infiltration were more inclined to HDO routes and produced more iso-alkanes (0.8 mol ratio of iso-alkanes/n-alkanes) than their counterparts prepared by conventional impregnation methods.