천연물로부터 여성갱년기 증상완화를 위한 식물성 에스트로겐의 초음파 추출특성

이승범; 박소연; 전길송; 홍인권; Seung Bum Lee; So Yeon Park; Gil Song Jeon; In Kwon Hong

Applied Chemistry for Engineering, Vol.27, No.2, 217-220, April, 2016

DOI10.14478/ace.2016.1023 Export Citation

천연물로부터 여성갱년기 증상완화를 위한 식물성 에스트로겐의 초음파 추출특성

Phytoestrogen Extraction for Relaxation of Female Menopause Symptoms from Natural Products

이승범 , 박소연, 전길송, 홍인권 ^†

단국대학교 화학공학과

Seung Bum Lee , So Yeon Park, Gil Song Jeon, and In Kwon Hong^†

Department of Chemical Engineering, Dankook University, Gyeonggi 16890, Korea

E-mail:

초록

식물성 에스트로겐은 내분비계에서 생성되지 않고 식물성 에스트로겐 식물을 먹음으로써 소비되는 유사에스트로겐이다. “식이 에스트로겐”으로도 불리는 식물성 에스트로겐은 자연적으로 발생하는 다양한 식물성 화합물 그룹이며, 에스트로겐과 구조적인 유사성 때문에 갱년기 증상을 감소시킴으로써 건강 증진에 기여할 수 있을 것이다. 본 연구에 서는 다양한 식물성 에스트로겐을 고삼, 석류, 칡으로부터 초음파공정을 이용하여 추출하였다. 다양한 초음파세기와 추출시간에서 식물성 에스트로겐의 추출 양을 비교하였다. 이로부터 얻은 결과는 천연물과 관련된 생화학적 연구에 기본적인 정보를 제공할 수 있을 것이다.

Phytoestrogens are one of quasi-estrogens which are not generated within the endocrine system, but consumed by intaking phytoestrogenic plants. Phytoestrogens, also called as “dietary estrogens”, are various botanic chemical compound groups naturally occurring nonsteroidal plant compounds of spontaneous generation. Due to their structural similarities to estrogone, they may provide desirable health benefits for reducing the menopausal symptoms. In this paper, various phytoestrogens were extracted from sophora root, pomegranate and kudzu by ultrasonic extraction process. In this study, the amount of extracted phytoestrogens at various ultrasonic power strengths and extraction times were compared, which could be used as basic data in the study of biology and chemistry related to natural products.

Keywords:phytoestrogen;menopausal symptom;ultrasonic extraction;natural product

[References]

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Park HM, Korean J. Obstet. Gynecol., 50(3), 389 (2007)

[Related Articles]

[1] Lazari MFM, Lucas TFG, Yasuhara F, Gomes GRO, Siu ER, Royer C, Fernandes SAF, Porto CS, Arq. Bras. Endocrinol. Metab., 53(8), 923 (2009)

[2] Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Physiol. Rev., 81(4), 1535 (2001)

[3] O’Donnell L, Robertson KM, Jones ME, Simpson ER, Endocr. Rev., 22(3), 289 (2001)

[4] Hess RA, Carnes K, Anim. Reprod., 1(1), 5 (2004)

[5] Kum EJ, Kwon DH, Shin HS, J. Food Hyg. Safety, 25(1), 79 (2010)

[6] Whittington R, Faulds D, Pharmacoeconomics, 5, 419 (1994)

[7] Cornwell T, Cohick W, Raskin I, Phytochemistry, 65(8), 995 (2004)

[8] Hays J, Ockene JK, Brunner RL, Kotchen JM, Manson JE, Patterson RE, Aragaki AK, Shumaker SA, Brzyski RG, LaCroix AZ, Granek IA, Valanis BG, N. Engl. J. Med., 348(19), 1839 (2003)

[9] Krebs EE, Ensrud KE, MacDonald R, Wilt TJ, Obstet. Gynecol., 104(4), 824 (2004)

[10] Dalais FS, Rice GE, Wahlqvist ML, Grehan M, Murkies AL, Medley G, Ayton R, Strauss BJG, Climacteric, 1, 124 (1998)

[11] Adelina R, Supriyati MD, Nawangsari DA, Jenie RI, Meiyanto E, I. J. Biotechnol., 13(2), 1092 (2008)

[12] Sirotkin AV, Eur. J. Pharmacol., 741, 230 (2014)

[13] Murkies AL, Wilcox G, Davis SR, J. Clin. Endocrinol. Metab., 83, 297 (1998)

[14] Hurst WJ, Method of Analysis for Functional Foods and Nutraceuticals, 2nd ed., CRC Press, New York (2008).

[15] Park HM, Korean J. Obstet. Gynecol., 50(3), 389 (2007)