Nanoporous multilayer films for controlled antigen protein release

Miso Yang; Daheui Choi; Moonhyun Choi; Jinkee Hong

Journal of Industrial and Engineering Chemistry, Vol.33, 221-225, January, 2016

DOI10.1016/j.jiec.2015.10.009 Export Citation

Nanoporous multilayer films for controlled antigen protein release

Miso Yang, Daheui Choi, Moonhyun Choi, and Jinkee Hong^†

School of Chemical Engineering and Material Science, Chung-Ang University, 47 Heukseok-ro, Dongjak-gu, Seoul 156-756, Republic of Korea

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We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.

Keywords:Nanoporous;Multilayer;Layer by layer;Gold nanoparticle;Protein delivery

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Burke SE, Barrett CJ, Biomacromolecules, 4(6), 1773 (2003)
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[Referenced By]

[1] Castner DG, Ratner BD, Surf. Sci., 500, 28 (2002)

[2] Gupta AK, Gupta M, Biomaterials, 26, 3995 (2005)

[3] Yoo HS, Kim TG, Park TG, Adv. Drug Deliv. Rev., 61, 1033 (2009)

[4] Su Y, Su Q, Liu W, Lim M, Venugopal JR, Mo X, Ramakrishna S, Al-Deyab SS, El-Newehy M, Acta Biomater., 8, 763 (2012)

[5] Wu S, Huang X, Du X, Angew. Chem.-Int. Edit., 52, 5580 (2013)

[6] Wu T, Zhang Q, Ren W, Yi X, Zhou Z, Peng X, Yu X, Lang M, J. Mater. Chem. B, 1, 3304 (2013)

[7] Min J, Braatz RD, Hammond PT, Biomaterials, 35, 2507 (2014)

[8] Liao LY, Liu J, Dreaden EC, Morton SW, Shopsowitz KE, Hammond PT, Johnson JA, J. Am. Chem. Soc., 136(16), 5896 (2014)

[9] Lomas H, Johnston AP, Such GK, Zhu Z, Liang K, Van Koeverden MP, Alongkornchotikul SF, Caruso Small, 7, 2109 (2011)

[10] Hong J, Shah NJ, Drake AC, DeMuth PC, Lee JB, Chen J, Hammond PT, ACS Nano, 6, 81 (2012)

[11] Choi D, Son B, Park TH, Hong J, Nanoscale, 7, 6703 (2015)

[12] Decher G, Science, 277(5330), 1232 (1997)

[13] Caruso F, Caruso RA, Mohwald H, Science, 282(5391), 1111 (1998)

[14] Vazquez E, Dewitt DM, Hammond PT, Lynn DM, J. Am. Chem. Soc., 124(47), 13992 (2002)

[15] Hammond PT, Adv. Mater., 16(15), 1271 (2004)

[16] Lvov Y, Ariga K, Ichinose I, Kunitake T, J. Am. Chem. Soc., 117(22), 6117 (1995)

[17] Cheung JH, Stockton WB, Rubner MF, Macromolecules, 30(9), 2712 (1997)

[18] Hyder MN, Lee SW, Cebeci FC, Schmidt DJ, Shao-Horn Y, Hammond PT, ACS Nano, 5, 8552 (2011)

[19] Stockton WB, Rubner MF, Macromolecules, 30(9), 2717 (1997)

[20] Kharlampieva E, Kozlovskaya V, Sukhishvili SA, Adv. Mater., 21(30), 3053 (2009)

[21] Duffy CV, David L, Crouzier T, Acta Biomater., 51, 2015

[22] Lu Y, Wu Y, Liang J, Libera MR, Sukhishvili SA, Biomaterials, 45, 64 (2015)

[23] van der Maaden K, Sekerdag E, Schipper P, Kersten G, Jiskoot W, Bouwstra J, Langmuir, 31, 8654 (2015)

[24] Shah NJ, Macdonald ML, Beben YM, Padera RF, Samuel RE, Hammond PT, Biomaterials, 32, 6183 (2011)

[25] Macdonald ML, Samuel RE, Shah NJ, Padera RF, Beben YM, Hammond PT, Biomaterials, 32, 1446 (2011)

[26] Han L, Zhao J, Zhang X, Cao W, Hu X, Zou G, Duan X, Liang XJ, ACS Nano, 6, 7340 (2012)

[27] Song W, Song X, Yang C, Gao S, Klausen LH, Zhang Y, Dong M, Kjems J, Int. J. Nanomed., 10, 2335 (2015)

[28] Chen X, Wu W, Guo Z, Xin J, Li J, Biomaterials, 32, 1759 (2011)

[29] Shukla A, Fang JC, Puranam S, Jensen FR, Hammond PT, Adv. Mater., 24(4), 492 (2012)

[30] Bernards DA, Lance KD, Ciaccio NA, Desai TA, Nano Lett., 12, 5355 (2012)

[31] Keller S, Wilson JT, Patilea GI, Kern HB, Convertine AJ, Stayton PS, J. Control. Release, 191, 24 (2014)

[32] Gittins DI, Caruso F, Angew. Chem.-Int. Edit., 40, 3001 (2001)

[33] Shiratori SS, Rubner MF, Macromolecules, 33(11), 4213 (2000)

[34] Burke SE, Barrett CJ, Biomacromolecules, 4(6), 1773 (2003)

[35] Schneider G, Decher G, Nerambourg N, Praho R, Werts MH, Blanchard-Desce M, Nano Lett., 6, 530 (2006)

[36] Su X, Kim BS, Kim SR, Hammond PT, Irvine DJ, ACS Nano, 3, 3719 (2009)