Numerical simulations of blood flow in arterial bifurcation models

Taewon Seo

Korea-Australia Rheology Journal, Vol.25, No.3, 153-161, August, 2013

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Numerical simulations of blood flow in arterial bifurcation models

Taewon Seo^†

Department of Mechanical and Automotive Engineering, Andong National Univ, Kyungdong-ro 1375, Andong, Gyeongsangbuk-do, 760-749, Republic of Korea

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In the study, two different arterial bifurcation model geometries were used in the flow simulation. The model 1 is assumed the internal carotid artery (ICA) and the external carotid artery (ECA) branches of the bifurcation aligned in parallel to each other, while the model 2 is the typical carotid geometry. In the computation the Non-Newtonian behavior of blood was described using Carreau model. Generally, in the comparison between Newtonian and Non-Newtonian results good agreement was observed in the velocity profiles, while some discrepancies were found in the temporal wall shear stress (WSS) distributions as well as pressure profiles due to the shear thinning behavior. The temporal evolution of WSS periodically increases and decreases closely that of the inlet velocity waveform. It was also observed that the reversed flow region in the ICA of model 2 is 2.5 times larger than that of model 1. As a result, the variation of the flow characteristics can be dependent on the geometry as well as the arterial bifurcation geometry plays an important role in the development of atherosclerosis.

Keywords:carotid sinus;bifurcation model;wall shear stress;atherosclerosis;blood flow

[References]

http://www.who.int/chp/chronic_disease_report/contents/part2.pdf, World Health Organization (2005)
Araim O, Chen AH, Sumpio B, Molecular Medicine., 1, 39 (2005)
Blanco PJ, Pivello MR, Feijoo RA, Urquiza S, Sensitivity of blood flow at the carotid artery to the heart inflow boundary condition, 3rd International Congress on Comput. Bioeng., Isla de Maragarita, Venezuela, 1 (2007)
Buchmann NA, Jermy MC, Blood flow measurements in idealized and patient specific models of the human carotid artery, 14th Int. Symp. On Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, 1 (2008)
Buchmann NA, Jermy MC, Particle image velocimetry measurements of blood flow in a modeled carotid artery bifurcation, 16th Australasian Fluid Mech, Cold Coast, Australia (2007)
Chen J, Lu XY, J. Biomech., 39, 818 (2006)
Fan Y, Jiang W, Zou Y, Li J, Chen J, Deng X, Acta Mech Sin., 25, 249 (2009)
Giddens DP, Zarins CK, Glagov S, Appl. Mech. Rev., 43, S98 (1990)
Gijsen FJH, van de Vosse FN, Janssen JD, J.Biomech., 32, 601 (1999)
Gupta AK, Int. J. Eng. Bus. Manag., 3, 1 (2011)
Jou LD, berger SA, Theoret. Comput. Fluid Dynamics., 10, 239 (1998)
Ku DN, Giddens DP, J.Biomech., 20, 407 (1987)
Lee BK, Xue S, Nam JH, Lim HJ, Shin SH, Korea-Aust. Rheol. J., 23, 1 (2011)
Lee SW, Antiga L, Spence D, Steinman DA, Stroke AHAJ., 39, 2341 (2008)
Ma P, Li X, Ku DN, J. Biomech., 30, 565 (1997)
Malek AM, Alper SL, Izumo S, JAMA., 282, 2035 (1999)
Rothwell PM, Goldstein LB, Stroke., 35, 2425 (2004)
Seo TW, Schachter LG, Barakat AI, Ann. Biomed. Eng., 33(4), 444 (2005)
Shaik E, Hoffmann KA, Dietiker JF, Numerical flow simulations of blood in arteries, 4th AIAA Aerospace Science Meeting and Exhibit, Reno, Nevada, USA, 294 (2006)
Shibeshi SS, Collins WE, Appl. Rheol., 15(6), 398 (2005)
Valencia A, Zarate A, Galvez M, Badilla L, Int. J. Numer. Meth. Fluids., 50, 751 (2006)
Wake AK, Modeling fluid mechanics in individual human carotid arteries, Dissertation, Georgia Institute of Technology (2005)
Walker MD, Marler JR, Grady PA, Toole JF, Baker WH, Castaldo JE, Chambless LE, Moore WS, Robertson JT, Young B, J. American Medical Association., 273(18), 1421 (1995)
Womersley JR, J. Physiol., 127, 553 (1955)
Zhao SZ, Xu XY, Hughes AD, Thom SA, Stanton AV, Ariff B, Long Q, J. of Biomech., 33, 975 (2000)

[Referenced By]

[1] http://www.who.int/chp/chronic_disease_report/contents/part2.pdf, World Health Organization (2005)

[2] Araim O, Chen AH, Sumpio B, Molecular Medicine., 1, 39 (2005)

[3] Blanco PJ, Pivello MR, Feijoo RA, Urquiza S, Sensitivity of blood flow at the carotid artery to the heart inflow boundary condition, 3rd International Congress on Comput. Bioeng., Isla de Maragarita, Venezuela, 1 (2007)

[4] Buchmann NA, Jermy MC, Blood flow measurements in idealized and patient specific models of the human carotid artery, 14th Int. Symp. On Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, 1 (2008)

[5] Buchmann NA, Jermy MC, Particle image velocimetry measurements of blood flow in a modeled carotid artery bifurcation, 16th Australasian Fluid Mech, Cold Coast, Australia (2007)

[6] Chen J, Lu XY, J. Biomech., 39, 818 (2006)

[7] Fan Y, Jiang W, Zou Y, Li J, Chen J, Deng X, Acta Mech Sin., 25, 249 (2009)

[8] Giddens DP, Zarins CK, Glagov S, Appl. Mech. Rev., 43, S98 (1990)

[9] Gijsen FJH, van de Vosse FN, Janssen JD, J.Biomech., 32, 601 (1999)

[10] Gupta AK, Int. J. Eng. Bus. Manag., 3, 1 (2011)

[11] Jou LD, berger SA, Theoret. Comput. Fluid Dynamics., 10, 239 (1998)

[12] Ku DN, Giddens DP, J.Biomech., 20, 407 (1987)

[13] Lee BK, Xue S, Nam JH, Lim HJ, Shin SH, Korea-Aust. Rheol. J., 23, 1 (2011)

[14] Lee SW, Antiga L, Spence D, Steinman DA, Stroke AHAJ., 39, 2341 (2008)

[15] Ma P, Li X, Ku DN, J. Biomech., 30, 565 (1997)

[16] Malek AM, Alper SL, Izumo S, JAMA., 282, 2035 (1999)

[17] Rothwell PM, Goldstein LB, Stroke., 35, 2425 (2004)

[18] Seo TW, Schachter LG, Barakat AI, Ann. Biomed. Eng., 33(4), 444 (2005)

[19] Shaik E, Hoffmann KA, Dietiker JF, Numerical flow simulations of blood in arteries, 4th AIAA Aerospace Science Meeting and Exhibit, Reno, Nevada, USA, 294 (2006)

[20] Shibeshi SS, Collins WE, Appl. Rheol., 15(6), 398 (2005)

[21] Valencia A, Zarate A, Galvez M, Badilla L, Int. J. Numer. Meth. Fluids., 50, 751 (2006)

[22] Wake AK, Modeling fluid mechanics in individual human carotid arteries, Dissertation, Georgia Institute of Technology (2005)

[23] Walker MD, Marler JR, Grady PA, Toole JF, Baker WH, Castaldo JE, Chambless LE, Moore WS, Robertson JT, Young B, J. American Medical Association., 273(18), 1421 (1995)

[24] Womersley JR, J. Physiol., 127, 553 (1955)

[25] Zhao SZ, Xu XY, Hughes AD, Thom SA, Stanton AV, Ariff B, Long Q, J. of Biomech., 33, 975 (2000)