5-플루오로우라실을 포함하는 단량체와 중합체의 노랑초파리에 대한 생리유전학적 영향

이능주; 김익성; 최원문; 하창식; 조원제

Journal of the Korean Industrial and Engineering Chemistry, Vol.2, No.1, 56-63, March, 1991

Export Citation

5-플루오로우라실을 포함하는 단량체와 중합체의 노랑초파리에 대한 생리유전학적 영향

Physiological Genetic Effects of Monomer and Polymer Containing 5-Fluorouracil on Drosophila Melanogaster

이능주, 김익성, 최원문, 하창식, 조원제

초록

1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU)을 trans-β-carbomethoxyacryl chlocide와 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine으로부터 합성하고, CMAFU 와 메틸메타크릴레이트를 cyclohexanone 을 용매로 사용하여 60 ℃ 에서 라디칼공중합을 하였다. 5-FU, CMAFU 및 poly(CMAFU-Co-MMA)들이 노랑초파리에 미치는 생리유전학적 영향을 Lewis와 Bacher 방법에 의하여 조사한 결과, CMAFU 와 그 중합체가 5-FU 보다 생리유전학적 영향이 약함을 알 수 있었다.

The monomer, 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) was synthesized from trans-β-carbomethoxyacryl chloride and 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine. A copolymer of CMAFU with methyl methacrylate (MMA) [poly(CMAFU-co-MMA)] was also prepared with 2, 2'-azobisisobutyronitrile in cyclohexanone at 60 ℃. Physiological genetic effects of 5-fluorouracil(5-FU), CMAFU and poly(CMAFU-co-MMA) on Drosophila melanogaster were investigated by the adult feeding method of Lewis and Bacher. It was found that a physiological genetic effect on the Drosophila melanogaster was considerably weaker for CMAFU and its copolymer than 5-FU.

[References]

Auerbach C, Roboson JM, Proc. Roy. Soci. Edinb., 62, 271 (1947)
Alderson TA, Nature, 207, 164 (1965)
Bosch L, Horbers E, Heidelberger C, Cancer Rev., 18, 335 (1958)
Bounous G, Pageau R, Regoli D, J. Chem. Pharmacol. Biopharm., 16, 519 (1978)
Heidelberger C, Proc. Nucleic Acid. Res. Mol. Biol., 4, 1 (1965)
Myers CE, Pharmacol. Rev., 33, 1 (1981)
Oda Y, Mutation Res., 183, 103 (1987)
Duke EJ, Glassman E, Nature, 220, 588 (1968)
Umrigar PP, Ohashi S, Butler GB, J. Polym. Sci. A: Polym. Chem., 17, 351 (1979)
Gebelein GG, Morgan RM, Polym. Prepr., 18(1), 811 (1977)
Akashi M, Beppu K, Kikuchi I, Miyauchi N, J. Macromol. Sci.-Chem., A23, 1233 (1986)
Akashi M, Tanaka Y, Miyazaki T, Miyauchi N, J. Bioactive Compatible Polym., 2, 120 (1987)
Lewis EB, Bacher F, Drosophila Inform. Ser., 43, 193 (1986)
Sankaranarayan K, Sobels FH, "The Genetics and Biology of Drosophila, Radiation Genetics," U.S.A. Academic Press, p. 1089 (1976)
Inoue Y, Watanabe TK, Jpn. J. Genetics, 53(3), 183 (1978)

[Referenced By]

[1] Auerbach C, Roboson JM, Proc. Roy. Soci. Edinb., 62, 271 (1947)

[2] Alderson TA, Nature, 207, 164 (1965)

[3] Bosch L, Horbers E, Heidelberger C, Cancer Rev., 18, 335 (1958)

[4] Bounous G, Pageau R, Regoli D, J. Chem. Pharmacol. Biopharm., 16, 519 (1978)

[5] Heidelberger C, Proc. Nucleic Acid. Res. Mol. Biol., 4, 1 (1965)

[6] Myers CE, Pharmacol. Rev., 33, 1 (1981)

[7] Oda Y, Mutation Res., 183, 103 (1987)

[8] Duke EJ, Glassman E, Nature, 220, 588 (1968)

[9] Umrigar PP, Ohashi S, Butler GB, J. Polym. Sci. A: Polym. Chem., 17, 351 (1979)

[10] Gebelein GG, Morgan RM, Polym. Prepr., 18(1), 811 (1977)

[11] Akashi M, Beppu K, Kikuchi I, Miyauchi N, J. Macromol. Sci.-Chem., A23, 1233 (1986)

[12] Akashi M, Tanaka Y, Miyazaki T, Miyauchi N, J. Bioactive Compatible Polym., 2, 120 (1987)

[13] Lewis EB, Bacher F, Drosophila Inform. Ser., 43, 193 (1986)

[14] Sankaranarayan K, Sobels FH, "The Genetics and Biology of Drosophila, Radiation Genetics," U.S.A. Academic Press, p. 1089 (1976)

[15] Inoue Y, Watanabe TK, Jpn. J. Genetics, 53(3), 183 (1978)