The mechanical properties and morphologies of poly(L-lactide) (PLLA) fibers, prepared by spinning in different vapor precipitants and hot drawing afterward, were studied in relation to fiber in vitro degradability. Petrolether, methanol, and ethanol were employed as precipitants. PLLA was used as-polymerized, i.e., with 10% of residual L-lactide. The tensile strength, structure, and degradability of obtained fibers were mainly governed by the nonsolvent concentration in the vapor phase. Using methanol as the precipitant for the fiber preparation, total tensile strength loss was achieved during 12 wk of in, vitro degradation.