The mechanical properties and morphology of poly(L-lactide) fibers, prepared by the dry spinning-hot drawing process using different nonsolvent/chloroform spinning solutions, were studied in relation to fiber in vitro degradability. Acetone, methanol, ethanol, and cyclohexane were used as nonsolvents in the spinning mixture with as-polymerized PLLA, i.e., PLLA containing 10% of residual L-lactide. The tensile strength, structure, and degradability of obtained fibers were mainly governed by the nonsolvent volatility. Generally, the higher the volatility, the higher the strength, and the faster the degradation. The acetone/ chloroform spinning system produced fiber with an increased degradation rate in comparison to the pure chloroform spinning system.