Experimental solubility data were measured for deflazacort dissolved in binary n-hexane + acetone, n-hexane + ethyl acetate, n-hexane + ethanol, and n-hexane + 2-propanol solvent mixtures at 303.15 K and atmospheric pressure by laser monitoring technique. Results of these measurements were used to test the predictive ability of the combined nearly ideal binary solvent (NIBS)/Redlich-Kister model. Computation showed that the model fit the data well.