The solubility of podophyllotoxin (furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl), (5R,5aR,8aR,9R)) in ethanol, methanol, acetone, ethyl acetate, propan-2-ol, and butan-l-of from (283.2 to 323.2) K was measured under atmospheric pressure. The solubility of podophyllotoxin in these solvents increases with increasing temperature. The solubility values were correlated with the Apelblat equation.