| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
5-Flourouracil Release from the Three Different Biodegradable Thermosensitive Poly(organophosphazene) Gels |
| 초록 |
Biodegradable and thermosensitive poly(organophosphazenes) bearing hydrophobic amino acid esters and hydrophilic MPEG along with hydrolysis-sensitive depsipeptide were synthesized. 5-Fluorouracil (5-FU), a representative anticancer drug, was physically mixed with poly(organophosphazenes) solutions at 4 ℃. These poly(organophosphazenes) solutions containing 5-FU were formed to the hydrogels at 37 ℃. We studied the 5-FU release behaviors from poly(organophsophazenes) hydrogels under various conditions. 5-FU loaded in the hydrogels was released over 2 weeks and its release rate was affected by the gel properties. |
| 저자 |
허정윤1, 이선미1, 안철희2, 송수창1
|
| 소속 |
1한국과학기술(연), 2서울대 |
| 키워드 |
poly(organophosphazene); 5-fluorouracil
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| E-Mail |
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