| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.258 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Asymmetrically Microporous PLGA/Pluronic F127 Membrane for Effective Guided Bone Regeneration: Preliminary Animal Study |
| 초록 | Bone healing is one of the important phenomena in clinical fields including oral, maxillofacial, orthopedic, and plastic surgeries. In general, a major obstacle in bone healing involves the rapid appearance of connective tissue. The presence of connective tissue at the bone defect site prevents osteogenesis, resulting in the incomplete bone formation having low mechanical strength and cartilage-like tissue.1 To prevent connective tissue infiltration into the bone defect site, guide bone regeneration (GBR) membranes made of some natural and synthetic polymers, such as collagen, expanded polytetrafluoroethylene, polylactic acid, polyglycolic acid, and poly(DL-lactic-co-glycolic acid) (PLGA), have been used.2 However, their fast absorption or non-absorption, brittleness, and permeability are still remained as limitations. In our previous study, we prepared GBR membranes with asymmetrical submicron pore sizes (to prevent connective tissue infiltration), hydrophilicity (for effective oxygen and nutrient permeation), and flexibility (to prevent surrounding tissue damages) by blending PLGA and a small amount of Pluronic F127 using a modified immersion precipitation method designed by our laboratory. In this study, a preliminary animal study using a rat model (skull bone defect; defect size, 8 mm) was carried out to compare bone healing ability among the control (blank), hydrophobic PLGA membrane, and hydrophilized PLGA/Pluronic F127 membrane. It was observed that the hydrophilized PLGA/F127 membrane has faster bone healing than control (blank) and hydrophobic PLGA membrane (그림 1). Fig. 1. Histological sections of 8 weeks after surgery; (a) control (blank), (b) PLGA membrane, (c) PLGA/F127 (5 wt%) membrane (*, host bone; arrow, new bone; H&E staining, x 40). Acknowledgement This work was supported by a grant from the Korea Ministry of Science and Technology (Grant No. RO5-2004-000-12629-0). References 1. A. Linde, et al., J. Periodontol., 64, 1116 (1993). 2. A. V. Imbronito, et al., Biomaterials, 23, 4079 (2002). |
| 저자 | 김준호1, 오세행1, 김진만2, 김은석2, 이진호1 |
| 소속 | 1한남대, 2충남대 |
| 키워드 | Guided bone regeneration; Biodegradable polymer; PLGA; Pluronics |
