화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관)
권호 34권 2호
발표분야 고분자 합성
제목 Targeting Cancer Cells with Heparin-Docetaxel Conjugates
초록 Docetaxel is important chemotherapeutic drug widely used today for the treatment of various types of cancer. Docetaxel is known to exert its therapeutic effect. However, the clinical usefulness of this drug is particularly hampered by their poor solubility. So they should be injected with Cremophor EL. Also these carriers need to be biocompatible, highly soluble, stable, capable of loading large amount of anticancer drugs, and able to conjugate with the targeting molecules. Heparin-docetaxel conjugates were designed a self assembled nanoparticles for using LMWH as a hydrophilic segment and Docetaxel as a hydrophobic segment. The chemical bonding of the conjugates was characterized by 1H-NMR, FT-IR, UV/Vis spectroscopy, dynamic light scattering(DLS), fluorescence spectroscopy. Finally, we describe LMWH-PTX nanoparticles for enhanced permeability and retention (EPR) effect and decreased other side effects.
저자 김유진1, 박일규2, 허강무2, 이용규3
소속 1충주대 화공생물공학과, 2충남대, 3충주대
키워드 Heparin; Docetaxel
E-Mail leeyk@cjnu.ac.kr