| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 신진 연구자 특별심포지움 |
| 제목 | Synthesis of Amino Acid Based Block Copolymers via Atom Transfer Radical Polymerization in Aqueous Media at Ambient Temperature |
| 초록 | Among the techniques that allow the synthesis of well-defined homopolymers and copolymers, atom transfer radical polymerization (ATRP) is one of the most useful systems, due to its tolerance of impurities, the ready availability of many kinds of initiators, catalysts and monomers, its mild reaction conditions, and its ability to produce polymers with predetermined molecular weights and narrow polydispersities. This paper describes (1) first, the successful polymerization of acryloyl β-alanine (ABA) via ATRP under near physiological conditions using various water soluble initiators with high yield and narrow molecular weight distributions. Controlled polymerization of amino acid-based monomers is important as a tool for synthesis of tailored polymers and copolymers for biomaterials and medical applications. Second, (2) block copolymerization of ABA with temperature sensitive monomer, n-isopropyl acrylamide (NIPAAm) via ATRP under environmentally friendly conditions. Their lower critical solution temperatures (LCST) were determined by cloud point measurements over a range of pH environments. 1H NMR spectroscopy, static light scattering, and gel permeation chromatography were used to determine polymer molecular weight and polydispersities. Future studies will focus on the use of ATRP to synthesize other amino acids based di- and tri-block amphiphilic copolymers, which may have use in biotechnology applications by fabrication self-assembled biocompatible micelles for hydrophobic drug delivery. |
| 저자 | 정일두 |
| 소속 | 부산대 |
| 키워드 | atom transfer radical polymerization; block copolymer; drug delivery; amphiphilic copolymer |
