| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 | 13권 2호, p.1759 |
| 발표분야 | 생물화공 |
| 제목 | In silico improvement of organisms using flux sum of metabolites |
| 초록 | This study presents an in silico method for improving strain performance on the basis of flux sum (Φ) of metabolites. The flux sum method first screens key metabolites that eventually increase production yield of useful substance by defining the metabolite utilization of an organism as flux sum with respect to the production of the target substance and perturbing the flux sum. Then, the method deletes and/or amplifes genes associated with aforementioned screened key metabolites. [This work was supported by the Korean Systems Biology Project of the Ministry of Science and Technology (M10309020000-03B5002-00000). Further supports by the LG Chem Chair Professorship and KOSEF through the CUPS are appreciated]. |
| 저자 | 김현욱, 김태용, 이상엽 |
| 소속 | 한국과학기술원 |
| 키워드 | strain improvement; flux sum |
| 원문파일 | 초록 보기 |
