| 초록 |
T-type calcium channels are strongly associated with the generation of rhythmical firing patterns in the mammalian CNS and implicated in pathogenesis of epilepsy and neuropathic pain. However, only limited progress has been made to date in the quest to identify both potent and selective compounds except kurtoxin and mibefradil for T-type channel blockade. For the development of potent and selective blockers, therefore, we have synthesized a series of 3,4-dihydroquinazoline derivatives and evaluated for their inhibitory activities against two subtype T-type and N-type calcium channels for SAR study. |
