| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Molecular weight of PEG-PA determines β-sheet to α-helix transition |
| 초록 |
Conventional amphiphilic block copolymers tend to self-assemble in water by random hydrophobically driven aggregation, whereas the secondary structural folding motifs such as α-helix and β-sheet affect the assembling process of the polypeptide-based polymers. Poly(L-alanine)10 and PEGylated poly(L-alanine)10 were used as a model system. L-polyalanine with a parallel β-sheeted structure transformed into a antiparallel structure and an α-helical structure in water, and the self-assembled morphology changed into a nanofibrous structure and a spherical micellar structure as the molecular weight of conjugated PEG increased. The sol-gel transition temperature did not follow a simple rule that more hydrophobic polymer has a lower transition temperature, suggesting that the nanoassembled pattern affects the transition temperature. The control of PEG molecular weight is very important not only in designing a PEG-polypeptide biomaterial but also in PEGylation of protein drug. |
| 저자 |
박민희, 최윤영, 장지혜, R. Balamurugan, 정병문
|
| 소속 |
이화여자대 |
| 키워드 |
polypeptide; secondary structure; sol-to-gel transition
|
| E-Mail |
|
