| 초록 |
Dendrimers are synthetic polymers with unique structures, which are a candidate for a peptide scaffold. Multiple antigen peptides were previously produced by using dendrimer and antigen peptides, which inspired me to design artificial proteins using dendrimers and the model peptides. We have designed collagen-mimic dendrimers by conjugating collagen model peptides, glycine-proline-(hydroxy)proline (GPP(O)) repeats, to dendrimers. The collagen-mimic dendrimers exhibited the collagen-like higher order structure and formed temperature-dependent hydrogels, indicating that collagen-mimic dendrimers are a potent artificial collagen materials. Additionally, we have prepared elastin-mimic dendrimers by using elastin model peptides, valine-proline-glycine-valine-glycine (VPGVG) repeats. The elastin-mimic dendrimers exhibited the temperature-dependent higher order structure. The dendrimers showed the phase transition, dependent in pH and salt concentration. |
