| 초록 |
Biodegradable polymer and hydrogel have been increasingly applied in many industrial, biomedical fields and pharmaceutics. Polyaspartic acid (PASP) is one of poly(amino acid)s with pendant carboxylic functional groups, which has been utilized as a dispersant, scale inhibitors, etc. This polymer can also be derivatized to useful biomedical materials via direct chemical modification or through reaction with polysuccinimide (PSI). Relatively high molecular weight (~105) PSI, the precursor polymer, is produced by thermal polycondensation of L-aspartic acid using phosphoric acid. PSI possesses succinimide ring structure on the backbone, which can be ring-opened by nucleophilic reagents, typically amines, to provide a variety of derivative polymers with different pendent structure and functionalities. Studies on the preparation and properties of the related polymers, which can be utilized as useful materials for environmental and biomedical applications, will be introduced. Also, preparation and swelling behavior of the polymer hydrogel based on PASP and the related polyaspartamide will be discussed. |
