| 초록 |
The hydrogel has been studied for various applications. In this study, we prepared sequential cross-linked collagen gels with collagen as a biomaterial, and acrylamide as a synthetic monomer. The elastic moduli (E) of cross-linked collagen gels were increased from 1.5 to 3.0 kPa by varying of acrylamide concentration. In addition, human dermal fibroblasts were encapsulated into the porous pores introduced into the gels, and cell growth and behavior were investigated. Increasing E of the gel led to decreases in cell growth rate, while the cellular GAG (glycosaminoglycan) production level was elevated. Overall, the growth and cellular activity of skin cells were influenced by the extracellular matrix properties of the collagen gels, and the results of this study will be highly useful for designing reconstructive skins, and further various tissue engineering researches. |
