| 학회 | 한국화학공학회 |
| 학술대회 | 2002년 봄 (04/26 ~ 04/27, 강원대학교) |
| 권호 | 8권 1호, p.1157 |
| 발표분야 | 생물화공 |
| 제목 | 원심법에 의한 얇은 아가로스 마이그로비즈의 인슐린에 의한 글루코스 응답곡선 평가를 위한 확산모델 |
| 초록 | A perifusion model for insulin secretion to glucose stimulation in the microencapsulated islets was developed. The model indicates that the behavior of insulin concentration depends on the first order delays in response, and the mass flow rates of glucose and insulin across the membrane. Although the time of the first order delay (T1) to approach the plateau level was longest among the time factors, the effect of the mass transport of insulin across agarose hydrogel had larger influence with increasing membrane thickness. The insulin concentration in the perfusate compartment for microencapsulated islets at a steady state depends on T1, the coefficient for proportional action, glucose concentration, the number of islet and perfusate flow rate without regard to the thickness of hydrogel. This model will be better understand the performance of a bioartificial pancreas so as to serve as a guide in designing a function of a BAP. |
| 저자 | 박영건 |
| 소속 | 전남대 |
| 키워드 | Perifusion model; Encapsulation; Bioartificial pancreas |
| 원문파일 | 초록 보기 |
