| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Synthesis of Herceptin functionalized drug delivery carriers for selective breast cancer cell destruction |
| 초록 |
Silica/titania nanosphere with cavity in its interior has been fabricated for drug delivery system. The fabricated nanosphere showed monodispersity and narrow size distribution (ca. 50 nm diameter) and fuctionalized with anti-[human epidermal growth factor receptor 2] monoclonal antibody (herceptin) for targeting human breast cancer cells (SK-BR-3). The apoptosis/necrosis and viability of HER-HNP-CPT-treated cells were investigated to evaluate in vitro antitumor efficacy. The viability of HER-HNP-CPT treated SK-BR-3 decreased to 60%, which demonstrated highly efficient chemotherapy. However, CPT loaded into HNP or HER-HNP had no significant effects on the viability of macrophages. In this study, the drug delivery efficiency of hollow nanosphere has been proved and suggests a new direction for its real application. |
| 저자 |
장윤선, 장정식
|
| 소속 |
서울대 |
| 키워드 |
drug delivery; herceptin; anti-cancer activity; hollow nanosphere
|
| E-Mail |
|
