| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of SIS content on the attachment and proliferation of conea endothelial cells on SIS/PLGA film |
| 초록 |
Abstract: Porcine small intestinal submucosa(SIS) derived from the submucosal layer of porcine intestine, both generate a minimal inflammatory response following implantation and have been approved by the FDA for many types of biomedical applications. Poly(lactic-co-glycolic acid)(PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. Also, it can be easily fabricated into many shapes. In this study, we fabricated natural/synthetic biomaterial hybrid film using 0, 10, 20, 40 and 80wt% of SIS. Conea endothelial cells(CECs) were seeded on SIS/PLGA film and confirmed the effects of adhesion and proliferation on CECs according to content of SIS. We confirmed that specific 10~20wt% SIS in SIS/PLGA films was superior to adhesion and proliferation of CECs and content of SIS such as 40wt% and 80wt% could not help cell growth and proliferation. This research suppose by SCRC (4110). |
| 저자 |
조은혜, 김수진, 이가영, 조수진, 성경열, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Small intestinal submucosa(SIS); Conea endothelial cell; SIS/PLGA film
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| E-Mail |
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