| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
콜로이드·계면화학_포스터 |
| 제목 |
Microscale Programmed Hydrogel Designed for Biomimetic Intestinal Organoids |
| 초록 |
The shrinkage or expansion of a hydrogel were widely used as sensitive scaffold, but limited prediction to volumetric changes in uncomplicated structure. In this study, we present that modeling of the shrinkage and expansion of responsive hydrogel using expansion ratio of hydrogel with structural ratio in a complicated hydrogel exposed to external stimuli. Then, we fabricated three-dimensional collagen villi scaffold using programed hydrogel reverse mold which can control dimeter of villi from 420 µm to 520 µm. As biomimetics, we cultured intestinal epithelial cells on three-dimensional collagen villi scaffold. In addition, to analyze the host-probiotics interaction in this hydrogel, co-cultured with Lactobacillus rhamnosus GG. Overall, these results will be highly useful for designing advanced tissue engineering scaffold that can enhance the quality of wide array of regenerated biomimetic tissues including three-dimensional villi. |
| 저자 |
신성규1, 송원석2, 안유진3, 정웅규3, 김윤곤1, 정재현1
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| 소속 |
1숭실대, 2서울대, 3UNIST |
| 키워드 |
Hydrogel; Expansion ratio; Biomimetic; Organoid
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| E-Mail |
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