| 초록 |
One of the serious complications that have not been solved yet in modern medicine is a post-operative tissue adhesion of internal organs. Tissue adhesion is associated with numerous post-operative complications, including patients pain, functional obstruction, and difficult re-operative surgery. To solve this problem, various polymer membranes as tissue adhesion barriers have been employed and commercialized. In this study, chitosan and poly(D,L-lactic-co-glycolic acid)(PLGA) with a small quantity of poly(ethylene oxide)(PEO) blend nanofibers were produced by electrospinning. Various ratio of the Chitosan/PLGA/PEO blend nanofibers were characterized by SEM, ATR-FTIR and antimicrobial test. Average diameter of chitosan-based nanofibers was controlled from 900 nm to 600 nm by adjustment of electrospinning conditions. |
